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dc.contributor.authorButcher, Annabelen
dc.contributor.authorOffeddu, Giovanni Sen
dc.contributor.authorOyen, Michelleen
dc.date.accessioned2014-12-16T15:31:11Z
dc.date.available2014-12-16T15:31:11Z
dc.date.issued2014-10-04en
dc.identifier.citationTrends in Biotechnology Volume 32, Issue 11, p564–570, November 2014. DOI: 10.1016/j.tibtech.2014.09.001en
dc.identifier.issn0167-7799
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246499
dc.description.abstractHydrogels closely resemble the extracellular matrix and can support cell proliferation while new tissue is formed, making them materials of choice as tissue engineering scaffolds. However, their sometimes poor mechanical properties can hinder their application. The addition of meshes of nanofibers embedded in their matrix forms a composite that draws from the advantages of both components. As these materials are still in the early stages of development, there is a lack of uniformity across methods for characterizing their mechanical properties. A simple metric to enable comparisons between materials is proposed. The fibrous constituent improves the mechanical properties of the hydrogel, while the biocompatibility and functionality of the gels is maintained or even improved.
dc.description.sponsorshipThe authors acknowledge the support of the EPSRC through a doctoral training award (ALB) and via the Nano Science and Technology Doctoral Training Centre (NanoDTC), EP/G037221/1 (GSO).
dc.languageEnglishen
dc.language.isoenen
dc.publisherCell Press (Elsevier)
dc.subjecthydrogelen
dc.subjectelectrospinningen
dc.subjectmechanical testingen
dc.subjectbiocompatibilityen
dc.subjectnanofibersen
dc.subjectcompositesen
dc.titleNanofibrous hydrogel composites as mechanically robust tissue engineering scaffoldsen
dc.typeArticle
dc.description.versionThis is the accepted manuscript. The final version is available from http://www.cell.com/trends/biotechnology/references/S0167-7799%2814%2900181-4.en
prism.endingPage570
prism.publicationDate2014en
prism.publicationNameTrends in Biotechnologyen
prism.startingPage564
prism.volume32en
dc.rioxxterms.funderEPSRC
dc.rioxxterms.projectidEP/G037221/1
dcterms.dateAccepted2014-09-04en
rioxxterms.versionofrecord10.1016/j.tibtech.2014.09.001en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-10-04en
dc.contributor.orcidOyen, Michelle [0000-0002-3428-748X]
dc.identifier.eissn1879-3096
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/G037221/1)
rioxxterms.freetoread.startdate2015-10-04


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