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Endoplasmic reticulum stress is induced in the human placenta during labour.


Type

Article

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Authors

Veerbeek, JHW 
Tissot Van Patot, MC 
Burton, GJ 
Yung, HW 

Abstract

Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to labour represents an in vivo model for the study of acute placental ER stress. ER stress markers, GRP78, P-eIF2α and XBP-1, were significantly higher in laboured placentas than in Caesarean-delivered controls localised mainly in the syncytiotrophoblast. The similarities to changes observed in PE/IUGR placentas suggest exposure to labour can be used to investigate induction of ER stress in pathological placentas.

Description

Keywords

Endoplasmic reticulum stress, Labour, Placenta, Cesarean Section, DNA-Binding Proteins, Endoplasmic Reticulum Chaperone BiP, Endoplasmic Reticulum Stress, Eukaryotic Initiation Factor-2, Female, Heat-Shock Proteins, Humans, Labor, Obstetric, Oxidative Stress, Parturition, Phosphorylation, Placenta, Pregnancy, Regulatory Factor X Transcription Factors, Transcription Factors, X-Box Binding Protein 1

Journal Title

Placenta

Conference Name

Journal ISSN

0143-4004
1532-3102

Volume Title

36

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (084804/Z/08/Z)
This study was funded by the Wellcome Trust (Grant No. 084804/2/08/Z) in UK and Ter Meulen Fund, Royal Netherlands Academy of Arts and Sciences in Netherlands.