Selective Lability of Ruthenium(II) Arene Amino Acid Complexes
Scrase, Tom G
O’Neill, Michael J
Senior, Paul W
Matthews, Peter D
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Scrase, T. G., O’Neill, M. J., Peel, A., Senior, P. W., Matthews, P. D., Shi, H., Boss, S., & et al. (2015). Selective Lability of Ruthenium(II) Arene Amino Acid Complexes. Inorganic Chemistry, 54 3118-3124. https://doi.org/10.1021/ic502051y
A series of organometallic complexes of the form [(PhH)Ru(Amino acid)]+ have been synthesized using amino acids able to act as tridentate ligands. The straightforward syntheses gave enantiomerically pure complexes with two stereogenic centres due to the enantiopurity of the chelating ligands. Complexes were characterized in the solid state and/or solution state where the stability of the complex allowed. The propensity towards labilization of the coordinatively saturated complexes was investigated. The link between complex stability and structural features are very subtle. Nonetheless, H/D exchange rates of coordinated amino groups reveal more significant differences in reactivity linked to metallocycle ring size resulting in decreasing stability of the metallocycle as the amino acid side chain length increases. The behavior of these systems in acid is unusual, apparently labilising the carboxylate residue of the amino acid. This acid-catalysed hemilability in an organometallic is relevant to the use of Ru(II) arenes in medicinal contexts due to the relatively low pH of cancerous cells.
ruthenium, organometallic, amino acid, acid-catalysed hemilability
TGS and MO thank the EPSRC for Studentships EP/P505445/1 and EP/K503/009/1, respectively.
External DOI: https://doi.org/10.1021/ic502051y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/246798
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/