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dc.contributor.authorDe, Tommasi Anna Sen
dc.contributor.authorOtranto, Domenicoen
dc.contributor.authorFurlanello, Tommasoen
dc.contributor.authorTasca, Silviaen
dc.contributor.authorCantacessi, Cinziaen
dc.contributor.authorBreitschwerdt, Edward Ben
dc.contributor.authorStanneck, Dorotheeen
dc.contributor.authorDantas-Torres, Filipeen
dc.contributor.authorBaneth, Gaden
dc.contributor.authorCapelli, Gioiaen
dc.contributor.authorde, Caprariis Donatoen
dc.date.accessioned2015-02-17T10:35:21Z
dc.date.available2015-02-17T10:35:21Z
dc.date.issued2014-12-02en
dc.identifier.citationAS De Tommasi, D Otranto, T Furlanello, S Tasca, C Cantacessi, EB Breitschwerdt, D Stanneck, F Dantas-Torres, G Baneth, G Capelli, D de Caprariis, Parasites & Vectors 2014, 7, 534.en
dc.identifier.issn1756-3305
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246813
dc.description.abstractBackground: Bone marrow (BM) is a major hematopoietic organ that can harbour a variety of vector-borne pathogens; however, knowledge of BM pathological changes in dogs infected with vector-borne pathogens is limited. Thus, the aim of the present study was to assess the pathological changes in canine BM associated with natural infections by four vector-borne pathogens, as well as to determine the relationships between such changes and abnormalities of the peripheral blood. Methods: Cytological disorders and pathological changes of the BM of 83 dogs naturally-infected with one or more of four vector-borne pathogens (i.e., Anaplasma platys, Leishmania infantum, Babesia vogeli and Hepatozoon canis) were evaluated and compared with the corresponding hematological findings. Results: Dysgranulopoiesis and dysmegakaryocytopoiesis were the most frequently observed BM abnormalities in infected dogs. Erythroid suppression, and lymphocytic, monocytic and macrophage hyperplasia were also observed. Interestingly, associations between suppression and hyperplasia of specific cell lines in the marrow and corresponding changes in numbers of circulating peripheral blood cells were not observed. Conclusions: Infections with one or more of the vector-borne pathogens examined in this study should be considered as differential diagnoses for secondary dysmyelopoiesis.
dc.description.sponsorshipThis research has been partially sponsored by Bayer Animal Health GmbH.
dc.languageEnglishen
dc.language.isoenen
dc.publisherBioMed Central
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectBone marrowen
dc.subjectCytologyen
dc.subjectVector-borne pathogensen
dc.subjectDysplasiaen
dc.subjectSecondary dysmyelopoiesisen
dc.titleEvaluation of blood and bone marrow in selected canine vector-borne diseasesen
dc.typeArticle
dc.description.versionThis paper was originally published in Parasites & Vectors (AS De Tommasi, D Otranto, T Furlanello, S Tasca, C Cantacessi, EB Breitschwerdt, D Stanneck, F Dantas-Torres, G Baneth, G Capelli, D de Caprariis, Parasites & Vectors 2014, 7, 534)en
prism.publicationDate2014en
prism.publicationNameParasites & Vectorsen
prism.startingPage534
prism.volume7en
dc.rioxxterms.funderBayer Animal Health GmbH
dcterms.dateAccepted2014-11-11en
rioxxterms.versionofrecord10.1186/s13071-014-0534-2en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-12-02en
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn1756-3305
rioxxterms.typeJournal Article/Reviewen


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales