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dc.contributor.authorAlcolea Delgado, Mariaen
dc.contributor.authorJones, Philipen
dc.date.accessioned2015-02-18T12:33:33Z
dc.date.available2015-02-18T12:33:33Z
dc.date.issued2015-01-20en
dc.identifier.citationMP Alcolea, PH Jones, Cell Cycle 2015, 14, 9-17en
dc.identifier.issn1538-4101
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246862
dc.description.abstractCell competition where ‘loser’ cells are eliminated by neighbors with higher fitness is a widespread phenomenon in development. However, a growing body of evidence argues cells with somatic mutations compete with their wild type counterparts in the earliest stages of cancer development. Recent studies have begun to shed light on the molecular and cellular mechanisms that alter the competitiveness of cells carrying somatic mutations in adult tissues. Cells with a ‘winner’ phenotype create clones which may expand into extensive fields of mutant cells within normal appearing epithelium, favoring the accumulation of further genetic alterations and the evolution of cancer. Here we focus on how mutations which disrupt the Notch signaling pathway confer a ‘super competitor’ status on cells in squamous epithelia and consider the broader implications for cancer evolution.
dc.description.sponsorshipWe acknowledge the support of the MRC, the NC3Rs (National Center for the Replacement, Refinement and Reduction of Animals in Research), the Wellcome Trust (Project grant WT090334MA, to PHJ), Cancer Research UK (Program Grant C609/A17257, to PHJ) and a European Union Marie Curie Fellowship (PIEF-LIF-2007-220016, to MPA).
dc.languageEnglishen
dc.language.isoenen
dc.publisherTaylor & Francis
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectcarcinogenesisen
dc.subjectcanceren
dc.subjectesophagusen
dc.subjectfield changeen
dc.subjectprogenitoren
dc.subjectsquamousen
dc.subjectstem cellen
dc.titleCell competition: Winning out by losing notchen
dc.typeArticle
dc.description.versionThis paper was originally published in Cell Cycle (MP Alcolea, PH Jones, Cell Cycle 2015, 14, 9-17)en
prism.endingPage17
prism.publicationDate2015en
prism.publicationNameCell Cycleen
prism.startingPage9
prism.volume14en
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNational Center for the Replacement, Refinement and Reduction of Animals in Research
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderCancer Research UK
dc.rioxxterms.funderEuropean Union Marie Curie Fellowship
dc.rioxxterms.projectidWT090334MA
dc.rioxxterms.projectidC609/A17257
dc.rioxxterms.projectidPIEF-LIF-2007-220016
rioxxterms.versionofrecord10.4161/15384101.2014.988027en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-01-20en
dc.contributor.orcidAlcolea Delgado, Maria [0000-0002-8396-6454]
dc.contributor.orcidJones, Philip [0000-0002-5904-795X]
dc.identifier.eissn1551-4005
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMedical Research Council (MC_UU_12022/3)
pubs.funder-project-idCancer Research UK (C609/A17257)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales