Cyclopropanation using flow-generated diazo compounds
Roda, Nuria M
Tran, Duc N
Ingham, Richard J
Hawkins, Joel M
Organic & Biomolecular Chemistry
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Roda, N. M., Tran, D. N., Battilocchio, C., Labes, R., Ingham, R. J., Hawkins, J. M., & Ley, S. (2015). Cyclopropanation using flow-generated diazo compounds. Organic & Biomolecular Chemistry, 13 2550-2554. https://doi.org/10.1039/C5OB00019J
We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.
We are grateful to Pfizer Worldwide Research and Development (CB, RJI and JMH), the Swiss National Science Foundation (DNT), CAPES (RL, no 9865/13-6) and the EPSRC (SVL, grant no EP/K0099494/1 and no EP/K039520/1) for financial support.
External DOI: https://doi.org/10.1039/C5OB00019J
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247078
Attribution-NonCommercial 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by-nc/2.0/uk/
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