Cyclopropanation using flow-generated diazo compounds.
Type
Article
Change log
Authors
Roda, Nuria M
Tran, Duc N
Battilocchio, Claudio https://orcid.org/0000-0002-4601-8527
Labes, Ricardo https://orcid.org/0000-0003-4001-0775
Ingham, Richard J
Abstract
We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.
Description
Keywords
Azo Compounds, Cyclopropanes, Molecular Structure
Journal Title
Org Biomol Chem
Conference Name
Journal ISSN
1477-0520
1477-0539
1477-0539
Volume Title
13
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
We are grateful to Pfizer Worldwide Research and Development
(CB, RJI and JMH), the Swiss National Science Foundation
(DNT), CAPES (RL, no 9865/13-6) and the EPSRC (SVL,
grant no EP/K0099494/1 and no EP/K039520/1) for financial
support.