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dc.contributor.authorDalskov, Stine-Mathildeen
dc.contributor.authorRitz, Christianen
dc.contributor.authorLarnkjær, Annien
dc.contributor.authorDamsgaard, Camilla Ten
dc.contributor.authorPetersen, Rikke Aen
dc.contributor.authorSørensen, Louise Ben
dc.contributor.authorOng, Kennethen
dc.contributor.authorAstrup, Arneen
dc.contributor.authorMølgaard, Christianen
dc.contributor.authorMichaelsen, Kim Fen
dc.date.accessioned2015-03-20T12:06:48Z
dc.date.available2015-03-20T12:06:48Z
dc.date.issued2014-12-22en
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, March 2015, 100(3):1196 –1205, DOI: 10.1210/jc.2014-3706en
dc.identifier.issn0021-972X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247094
dc.description.abstractBackground: Regulation of body composition during childhood is complex. Numerous hormones are potentially involved. Leptin has been proposed to restrain weight gain, but results are inconsistent. Objective: We examined whether baseline fasting levels of ghrelin, adiponectin, leptin, insulin, IGF-I, osteocalcin, and intact parathyroid hormone (iPTH) were associated with body composition cross sectionally and longitudinally in 633 8 –11-year-olds. Design: Data on hormones and body composition by dual-energy x-ray absorptiometry from the OPUS School Meal Study were used. We looked at baseline hormones as predictors of baseline fat mass index (FMI) or fat-free mass index (FFMI), and also subsequent changes (3 and 6 months) in FMI or FFMI using models with hormones individually or combined. Results: Cross-sectionally, baseline leptin was positively associated with FMI in girls (0.211 kg/m2pr. g/mL; 97.5% confidence interval [CI],0.186 – 0.236; P .001) and boys (0.231 kg/m2 pr. g/mL; 97.5% CI, 0.200 – 0.261; P .001). IGF-I in both sexes and iPTH in boys were positively associated with FMI. An inverse association between adiponectin and FFMI in boys and a positive association between IGF-I and FFMI were found in girls. In longitudinal models, baseline leptin was inversely associated with subsequent changes in FMI (0.018 kg/m2pr.g/mL; 97.5% CI, 0.034 –0.002; P .028) and FFMI (0.014 kg/m2 pr. g/mL; 97.5% CI, 0.024 –0.003; P .006) in girls. Conclusions: Cross-sectional findings support that leptin is produced in proportion to body fat mass, but the longitudinal observations support that leptin inhibits gains in FMI and FFMI in girls, a finding that may reflect preserved leptin sensitivity in this predominantly normal weight population. . (J Clin Endocrinol Metab 100: 1196 –1205, 2015)
dc.description.sponsorshipAddress all correspondence and requests for reprints to: Stine-Mathilde Dalskov, Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark. E-mail: smd@nexs.ku.dk. This study was registered inClinicalTrials.gov as trial number NCT01457794. The OPUS study was financed by a Grant from the Nordea Foundation (grant number 02-2010-478 0389). A complete list of food suppliers providing full or partial food sponsorships to the study can be found at the website: http://foodoflife.ku.dk/ opus/wp/skolemadsprojektet/leverandorer. Sources of funding and donation had no role in the trial design; collection, analysis, interpretation of data or decision to publish.
dc.languageEnglishen
dc.language.isoenen
dc.publisherEndocrine Society
dc.titleThe Role of Leptin and Other Hormones Related to Bone Metabolism and Appetite Regulation as Determinants of Gain in Body Fat and Fat-Free Mass in 8 –11-Year-Old Childrenen
dc.typeArticle
dc.description.versionThis is the accepted manuscript for a paper published in Journal of Clinical Endocrinology and Metabolism, March 2015, 100(3):1196 –1205, DOI: 10.1210/jc.2014-3706en
prism.endingPage1205
prism.publicationDate2014en
prism.publicationNameThe Journal of Clinical Endocrinology & Metabolismen
prism.startingPage1196
prism.volume100en
rioxxterms.versionofrecord10.1210/jc.2014-3706en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-12-22en
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.identifier.eissn1945-7197
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idMedical Research Council (MC_U106179472)


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