The aim of this review paper is to provide a comprehensive and up-to-date material for both researchers and professionals interested in Land-use-Transport Interaction (LUTI) modelling. The paper brings together some 60 years of published research on the subject. The review discusses the dominant theoretical and conceptual propositions underpinning research in the field, the existing operational LUTI modelling frameworks as well as the modelling methodologies that have been applied over the years. On the basis of these, the paper discusses the challenges, on-going progress and future research directions around the following thematic areas; [1] the challenges imposed by disaggregation—data availability, computation time, stochastic variation and output uncertainty; [2] the challenges of and progress in integrating activity-based travel demand models into LUTI Models; [3] the quest for a satisfactory measure of accessibility and ; [4] progress and challenges towards integrating the environment into LUTI Models.