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dc.contributor.authorCouton, Louiseen
dc.contributor.authorMauss, Alex Sen
dc.contributor.authorYunusov, Temuren
dc.contributor.authorDiegelmann, Soerenen
dc.contributor.authorEvers, Jan Felixen
dc.contributor.authorLandgraf, Matthiasen
dc.date.accessioned2015-03-24T11:35:23Z
dc.date.available2015-03-24T11:35:23Z
dc.date.issued2015-02-19en
dc.identifier.citationCouton L, Mauss AS, Yunusov T, Diegelmann S, Evers JF, Landgraf M, Current Biology 2015, 25, 568–576, doi:10.1016/j.cub.2014.12.056en
dc.identifier.issn0960-9822
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247164
dc.description.abstractBackground: Much of our understanding of how neural networks develop is based on studies of sensory systems, revealing often highly stereotyped patterns of connections, particularly as these diverge from the presynaptic terminals of sensory neurons. We know considerably less about the wiring strategies of motor networks, where connections converge onto the dendrites of motoneurons. Here, we investigated patterns of synaptic connections between identified motoneurons with sensory neurons and interneurons in the motor network of the Drosophila larva and how these change as it develops. Results: We find that as animals grow, motoneurons increase the number of synapses with existing presynaptic partners. Different motoneurons form characteristic cell-type-specific patterns of connections. At the same time, there is considerable variability in the number of synapses formed on motoneuron dendrites, which contrasts with the stereotypy reported for presynaptic terminals of sensory neurons. Where two motoneurons of the same cell type contact a common interneuron partner, each postsynaptic cell can arrive at a different connectivity outcome. Experimentally changing the positioning of motoneuron dendrites shows that the geography of dendritic arbors in relation to presynaptic partner terminals is an important determinant in shaping patterns of connectivity. Conclusions: In the Drosophila larval motor network, the sets of connections that form between identified neurons manifest an unexpected level of variability. Synapse number and the likelihood of forming connections appear to be regulated on a cell-by-cell basis, determined primarily by the postsynaptic dendrites of motoneuron terminals.
dc.description.sponsorshipL.C. was supported by a Fyssen Foundation post-doctoral fellowship. This work was supported by a Biotechnology and Biological Sciences Research Council (UK) grant (BB/I022414/1) to M.L., a Wellcome Trust Programme Grant (WT075934) to Michael Bate and M.L., a Grass Foundation fellowship to A.S.M., and a Sir Isaac Newton Trust grant to A.S.M. and M.L. The work benefited from facilities supported by a Wellcome Trust Equipment Grant (WT079204) and contributions by the Sir Isaac Newton Trust in Cambridge.
dc.languageEnglishen
dc.language.isoenen
dc.publisherCell Press
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleDevelopment of Connectivity in a Motoneuronal Network in Drosophila Larvaeen
dc.typeArticle
dc.description.versionThis paper was originally published in Current Biology (Couton L, Mauss AS, Yunusov T, Diegelmann S, Evers JF, Landgraf M, Current Biology 2015, 25, 568–576, doi:10.1016/j.cub.2014.12.056)en
prism.endingPage576
prism.publicationDate2015en
prism.publicationNameCurrent Biologyen
prism.startingPage568
prism.volume25en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderGrass Foundation
dc.rioxxterms.funderSir Isaac Newton Trust
dc.rioxxterms.funderFondation Fyssen
dc.rioxxterms.projectidBB/I022414/1
dc.rioxxterms.projectidWT075934
dc.rioxxterms.projectidWT079204
dcterms.dateAccepted2014-12-19en
rioxxterms.versionofrecord10.1016/j.cub.2014.12.056en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-02-19en
dc.contributor.orcidYunusov, Temur [0000-0001-9936-4354]
dc.contributor.orcidLandgraf, Matthias [0000-0001-5142-1997]
dc.identifier.eissn1879-0445
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/I022414/1)
pubs.funder-project-idWellcome Trust (079204/Z/06/Z)
pubs.funder-project-idWellcome Trust (075934/Z/04/Z)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales