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dc.contributor.authorPrasopdee, Sattrachaien
dc.contributor.authorTesana, Smarnen
dc.contributor.authorCantacessi, Cinziaen
dc.contributor.authorLaha, Thewarachen
dc.contributor.authorMulvenna, Jasonen
dc.contributor.authorGrams, Rudien
dc.contributor.authorLoukas, Alexen
dc.contributor.authorGallego, Javier Sotilloen
dc.date.accessioned2015-04-13T15:51:13Z
dc.date.available2015-04-13T15:51:13Z
dc.date.issued2014-10-02en
dc.identifier.citationJournal of Proteomics Volume 113, 15 January 2015, Pages 281–291. DOI: 10.1016/j.jprot.2014.09.018en
dc.identifier.issn1874-3919
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247309
dc.description.abstractThe snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver fluke Opisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand. The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host-parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection. To date most effort has focused on the interactions between the parasite and its human host, and little is known about the molecular relationships between the liver fluke and its snail intermediate host. In the present study we analyse the protein expression changes in different tissues of B. siamensis goniomphalos induced by infection with larval O. viverrini using iTRAQ labelling technology. We show that O. viverrini infection downregulates the expression of oxidoreductases and catalytic enzymes, while stress-related and motor proteins are upregulated. The present work could serve as a basis for future studies on the proteins implicated in the susceptibility/resistance of B. siamensis goniomphalos to O. viverrini, as well as studies on other pulmonate snail intermediate hosts of various parasitic flukes that infect humans.
dc.description.sponsorshipThis work was supported by project (613669) and program (1037304) grants from the National Health and Medical Research Council of Australia (NHMRC) and a Tropical Medicine Research Collaboration (TMRC) grant from the National Institute of Allergy and Infectious Disease, National Institutes of Health, USA (P50AI098639). AL is supported by a NHMRC principal research fellowship. Funding from Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (Grant No PHD/0027/2551) to SP and ST is also gratefully acknowledged.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.titleProteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis viverrinien
dc.typeArticle
dc.description.versionThis is the accepted manuscript. The final version is available from Elsevier at http://www.sciencedirect.com/science/article/pii/S1874391914004424.en
prism.endingPage291
prism.publicationDate2014en
prism.publicationNameJournal of Proteomicsen
prism.startingPage281
prism.volume113en
dcterms.dateAccepted2014-09-23en
rioxxterms.versionofrecord10.1016/j.jprot.2014.09.018en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-10-02en
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn1876-7737
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2015-10-02


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