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dc.contributor.authorChowdhury, Rajiven
dc.contributor.authorWarnakula, Samanthaen
dc.contributor.authorKunutsor, Setoren
dc.contributor.authorCrowe, Francescaen
dc.contributor.authorWard, Heather Aen
dc.contributor.authorJohnson, Lauraen
dc.contributor.authorFranco, Oscar Hen
dc.contributor.authorButterworth, Adamen
dc.contributor.authorForouhi, Nitaen
dc.contributor.authorThompson, Simonen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorMozaffarian, Dariushen
dc.contributor.authorDanesh, Johnen
dc.contributor.authorDi, Angelantonio Emanueleen
dc.date.accessioned2015-04-14T08:40:45Z
dc.date.available2015-04-14T08:40:45Z
dc.date.issued2014-03-18en
dc.identifier.citationChowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth A, Forouhi NG, Thompson SG, Khaw K-T, Mozaffarian D, Danesh J, Di Angelantonio E, Annals of Internal Medicine 2014, 160, 398-406, doi:10.7326/M13-1788en
dc.identifier.issn0003-4819
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247312
dc.description.abstractBackground: Guidelines advocate changes in fatty acid consumption to promote cardiovascular health. Purpose: To summarize evidence about associations between fatty acids and coronary disease. Data Sources: MEDLINE, Science Citation Index, and Cochrane Central Register of Controlled Trials through July 2013. Study Selection: Prospective, observational studies and randomized, controlled trials. Data Extraction: Investigators extracted data about study characteristics and assessed study biases. Data Synthesis: There were 32 observational studies (512 420 participants) of fatty acids from dietary intake; 17 observational studies (25 721 participants) of fatty acid biomarkers; and 27 randomized, controlled trials (105 085 participants) of fatty acid supplementation. In observational studies, relative risks for coronary disease were 1.03 (95% CI, 0.98 to 1.07) for saturated, 1.00 (CI, 0.91 to 1.10) for monounsaturated, 0.87 (CI, 0.78 to 0.97) for long-chain ω-3 polyunsaturated, 0.98 (CI, 0.90 to 1.06) for ω-6 polyunsaturated, and 1.16 (CI, 1.06 to 1.27) for trans fatty acids when the top and bottom thirds of baseline dietary fatty acid intake were compared. Corresponding estimates for circulating fatty acids were 1.06 (CI, 0.86 to 1.30), 1.06 (CI, 0.97 to 1.17), 0.84 (CI, 0.63 to 1.11), 0.94 (CI, 0.84 to 1.06), and 1.05 (CI, 0.76 to 1.44), respectively. There was heterogeneity of the associations among individual circulating fatty acids and coronary disease. In randomized, controlled trials, relative risks for coronary disease were 0.97 (CI, 0.69 to 1.36) for α-linolenic, 0.94 (CI, 0.86 to 1.03) for long-chain ω-3 polyunsaturated, and 0.86 (CI, 0.69 to 1.07) for ω-6 polyunsaturated fatty acid supplementations. Limitation: Potential biases from preferential publication and selective reporting. Conclusion: Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats. Primary Funding Source: British Heart Foundation, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, and Gates Cambridge.
dc.description.sponsorshipPrimary Funding Source: British Heart Foundation, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, and Gates Cambridge.
dc.languageEnglishen
dc.language.isoenen
dc.publisherAmerican College of Physicians
dc.titleAssociation of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysisen
dc.typeArticle
dc.description.versionThis is the prepublication, author-produced version of a manuscript accepted for publication in Annals of Internal Medicine. This version does not include post-acceptance editing and formatting. The American College of Physicians, the publisher of Annals of Internal Medicine, is not responsible for the content or presentation of the author-produced accepted version of the manuscript or any version that a third party derives from it. Readers who wish to access the definitive published version of this manuscript and any ancillary material related to this manuscript (e.g., correspondence, corrections, editorials, linked articles) should go to Annals.org or to the print issue in which the article appears. Those who cite this manuscript should cite the published version, as it is the official version of record. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth A, Forouhi NG, Thompson SG, Khaw K-T, Mozaffarian D, Danesh J, Di Angelantonio E, Annals of Internal Medicine 2014, 160, 398-406, doi:10.7326/M13-1788en
prism.endingPage406
prism.publicationDate2014en
prism.publicationNameAnnals of Internal Medicineen
prism.startingPage398
prism.volume160en
dc.rioxxterms.funderBritish Heart Foundation
dc.rioxxterms.funderMedical Research Council
dc.rioxxterms.funderCambridge National Institute for Health Research Biomedical Research Centre
dc.rioxxterms.funderGates Cambridge
rioxxterms.versionofrecord10.7326/M13-1788en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-03-18en
dc.contributor.orcidChowdhury, Rajiv [0000-0003-4881-5690]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidThompson, Simon [0000-0002-5274-7814]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.identifier.eissn1539-3704
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000143)
pubs.funder-project-idMRC (MC_UU_12015/5)
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idMRC (G0401527)
pubs.funder-project-idNational Institute for Health Research (NIHR) (NF-SI-0512-10114)
pubs.funder-project-idNational Institute for Health Research (NIHR) (NF-SI-0512-10165)


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