Activin/Nodal signalling in stem cells
The Company of Biologists
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Pauklin, S., & Vallier, L. (2015). Activin/Nodal signalling in stem cells. Development, 142 607-619. https://doi.org/10.1242/dev.091769
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
Activin, Cell cycle, Differentiation, Nodal, Pluripotency, Stem cells
S.P. was supported by the EUFP7 grant InnovaLIV and an FEBS long-term fellowship. L.V. was supported by the ERC starting grant Relieve IMDs and the Cambridge Hospitals National Institute for Health Research Biomedical Research Centre.
European Research Council (281335)
External DOI: https://doi.org/10.1242/dev.091769
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247423