Activin/Nodal signalling in stem cells.
The Company of Biologists
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Pauklin, S., & Vallier, L. (2015). Activin/Nodal signalling in stem cells.. Development, 142 607-619. https://doi.org/10.1242/dev.091769
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
Activin, Cell cycle, Differentiation, Nodal, Pluripotency, Stem cells
S.P. was supported by the EUFP7 grant InnovaLIV and an FEBS long-term fellowship. L.V. was supported by the ERC starting grant Relieve IMDs and the Cambridge Hospitals National Institute for Health Research Biomedical Research Centre.
Medical Research Council (G1000847)
Medical Research Council (G0800784)
Medical Research Council (G0701448)
European Research Council (281335)
External DOI: https://doi.org/10.1242/dev.091769
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247423