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dc.contributor.authorWright, Paulen
dc.contributor.authorRandall, Billien
dc.contributor.authorClarke, Alexen
dc.contributor.authorTyler, Lorraineen
dc.date.accessioned2015-04-22T11:41:01Z
dc.date.available2015-04-22T11:41:01Z
dc.date.issued2015-01-29en
dc.identifier.citationWright et al. Neuropsychologia (2015) Vol. 76, pp. 192-207. DOI: 10.1016/j.neuropsychologia.2015.01.041en
dc.identifier.issn0028-3932
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247424
dc.description.abstractThe anterior temporal lobe (ATL) plays a prominent role in models of semantic knowledge, although it remains unclear how the specific subregions within the ATL contribute to semantic memory. Patients with neurodegenerative diseases, like semantic dementia, have widespread damage to the ATL thus making inferences about the relationship between anatomy and cognition problematic. Here we take a detailed anatomical approach to ask which substructures within the ATL contribute to conceptual processing, with the prediction that the perirhinal cortex (PRc) will play a critical role for concepts that are more semantically confusable. We tested two patient groups, those with and without damage to the PRc, across two behavioural experiments – picture naming and word–picture matching. For both tasks, we manipulated the degree of semantic confusability of the concepts. By contrasting the performance of the two groups, along with healthy controls, we show that damage to the PRc results in worse performance in processing concepts with higher semantic confusability across both experiments. Further by correlating the degree of damage across anatomically defined regions of interest with performance, we find that PRc damage is related to performance for concepts with increased semantic confusability. Our results show that the PRc supports a necessary and crucial neurocognitve function that enables fine-grained conceptual processes to take place through the resolution of semantic confusability.
dc.description.sponsorshipThis work was supported by funding from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement no. 249640 to LKT.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectPerirhinal cortexen
dc.subjectAnterior temporal lobeen
dc.subjectConceptsen
dc.subjectSemanticsen
dc.subjectPatientsen
dc.subjectConfusabilityen
dc.titleThe perirhinal cortex and conceptual processing: Effects of feature-based statistics following damage to the anterior temporal lobesen
dc.typeArticle
dc.description.versionThis is the final published version. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.neuropsychologia.2015.01.041en
prism.endingPage207
prism.publicationDate2015en
prism.publicationNameNeuropsychologiaen
prism.startingPage192
prism.volume76en
dc.rioxxterms.funderERC
dc.rioxxterms.funderEU FP7
dc.rioxxterms.projectid249640
dcterms.dateAccepted2015-01-14en
rioxxterms.versionofrecord10.1016/j.neuropsychologia.2015.01.041en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-01-29en
dc.contributor.orcidClarke, Alex [0000-0001-7768-5229]
dc.contributor.orcidTyler, Lorraine [0000-0002-9943-118X]
dc.identifier.eissn1873-3514
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (249640)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales