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dc.contributor.authorWeinert, Lucy
dc.contributor.authorChaudhuri, Roy R
dc.contributor.authorWang, Jinhong
dc.contributor.authorMaskell, Sarah
dc.contributor.authorCorander, Jukka
dc.contributor.authorJombart, Thibaut
dc.contributor.authorBaig, Abiyad
dc.contributor.authorHowell, Kate J
dc.contributor.authorVehkala, Minna
dc.contributor.authorVälimäki, Niko
dc.contributor.authorHarris, David
dc.contributor.authorChieu, Tran Thi Bich
dc.contributor.authorVan Vinh Chau, Nguyen
dc.contributor.authorCampbell, James
dc.contributor.authorSchultsz, Constance
dc.contributor.authorParkhill, Julian
dc.contributor.authorBentley, Stephen D
dc.contributor.authorLangford, Paul R
dc.contributor.authorRycroft, Andrew N
dc.contributor.authorWren, Brendan W
dc.contributor.authorFarrar, Jeremy
dc.contributor.authorBaker, Stephen
dc.contributor.authorHoa, Ngo Thi
dc.contributor.authorHolden, Matthew TG
dc.contributor.authorTucker, Alexander
dc.contributor.authorMaskell, Duncan
dc.contributor.authorBRaDP1T Consortium
dc.date.accessioned2015-04-30T11:39:13Z
dc.date.available2015-04-30T11:39:13Z
dc.date.issued2015-03-31
dc.identifier.citationNature Communications 6, Article number: 6740, doi: 10.1038/ncomms7740
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247497
dc.description.abstractStreptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed clinical phenotypes from pigs and humans from the United Kingdom and Vietnam. Here, we show that isolates associated with disease contain substantially fewer genes than non-clinical isolates, but are more likely to encode virulence factors. Human disease isolates are limited to a single-virulent population, originating in the 1920, s when pig production was intensified, but no consistent genomic differences between pig and human isolates are observed. There is little geographical clustering of different S. suis subpopulations, and the bacterium undergoes high rates of recombination, implying that an increase in virulence anywhere in the world could have a global impact over a short timescale.
dc.description.sponsorshipThis work was supported by a Longer and Larger (LoLa) grant from the Biotechnology and Biological Sciences Research Council (grant numbers BB/G020744/1, BB/G019177/1, BB/G019274/1 and BB/G003203/1), the UK Department for Environment, Food and Rural Affairs and Zoetis, awarded to the Bacterial Respiratory Diseases of Pigs: 1 Technology (BRaDP1T) consortium. Part of this work was supported by The Wellcome Trust Overseas Programme in Vietnam (2010–2015) (089276/Z/09/Z) and the Vietnam Initiative on Zoonotic Infections (VIZIONS) award (WT/093724/Z/10/Z). S.D.B. is partly funded by the NIHR Cambridge BRC.
dc.languageEnglish
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.titleGenomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.
dc.typeArticle
dc.description.versionThis is the final published version. It first appeared at http://www.nature.com/ncomms/2015/150331/ncomms7740/full/ncomms7740.html.
prism.number6740
prism.publicationDate2015
prism.publicationNameNat Commun
prism.volume6
dc.rioxxterms.funderBBSRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidBB/G020744/1
dc.rioxxterms.projectidBB/G019177/1
dc.rioxxterms.projectidBB/G019274/1
dc.rioxxterms.projectidBB/G003203/1
dc.rioxxterms.projectid089276/Z/09/Z
dc.rioxxterms.projectidWT/093724/Z/10/Z
dcterms.dateAccepted2015-02-24
rioxxterms.versionofrecord10.1038/ncomms7740
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-03-31
dc.contributor.orcidWeinert, Lucy [0000-0002-9279-6012]
dc.contributor.orcidWang, Jinhong [0000-0001-9773-1317]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcidBaker, Stephen [0000-0003-1308-5755]
dc.contributor.orcidTucker, Alexander [0000-0003-0062-0843]
dc.contributor.orcidMaskell, Duncan [0000-0002-5065-653X]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/G019274/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L003902/1)
pubs.funder-project-idWellcome Trust (100891/Z/13/Z)
cam.issuedOnline2015-03-31


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales