Surface-immobilised micelles via cucurbituril-rotaxanes for solvent-induced burst release
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Hu, C., Zheng, Y., Yu, Z., Abell, C., & Scherman, O. (2015). Surface-immobilised micelles via cucurbituril-rotaxanes for solvent-induced burst release. Chemical Communications, 51 4858-4860. https://doi.org/10.1039/C5CC00121H
The fabrication, characterisation and controlled burst release of naphthol-functionalised micellar (NFM) nanostructures, which were grafted onto gold surfaces through cucurbituril (CB) mediated host-guest interactions are described. NFMs undergo a facile change in morphology from micelles to diblock copolymers in direct response to exposure to organic solvents, including tetrahydrofuran (THF), toluene and chloroform. This induced transition in conformation lends itself to potential applications including nanocarriers for triggered burst-release of guest molecules. Nile Red was investigated as a NFM encapsulated model hydrophobic cargo inside the surface-attached micelles, which could be fully released upon exposure to THF as measured by both atomic force microscopy and UV/vis spectroscopy.
C. Hu thanks BP for supporting this work and Hughes Hall College Cambridge for a student scholarship. Y. Zheng was supported by an ERC starting investigator grant (ASPiRe 240629). Z. Yu is supported by an EPSRC grant (EP/H046593/1).
European Research Council (240629)
External DOI: https://doi.org/10.1039/C5CC00121H
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247601
Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/