Mirror image phosphoinositides regulate autophagy
Molecular and Cellular Oncology
Taylor & Francis
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Vicinanza, M., & Rubinsztein, D. C. (2015). Mirror image phosphoinositides regulate autophagy. Molecular and Cellular Oncology, 3 (e1019974)https://doi.org/10.1080/23723556.2015.1019974
Autophagosome formation is stimulated by canonical VPS34-dependent PI(3)P formation, which recruits effectors, like WIPI2. However, non-canonical VPS34-independent autophagy has been proposed. We recently described that PI(5)P regulates autophagosome biogenesis, recruits WIPI2 and rescues autophagy in VPS34-inactivated cells. These alternative autophagy-initiating pathways reveal new druggable targets for treating neurodegeneration and cancer.
We are grateful for funding from a Wellcome Trust Principal Research Fellowship (DCR) (095317/Z/11/Z), a Wellcome Trust Strategic Award (100140/Z/12/Z), The NIHR Biomedical Research Centre in Dementia at Addenbrooke’s Hospital, and an MRC Confidence in Concepts grant (DCR) for funding.
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External DOI: https://doi.org/10.1080/23723556.2015.1019974
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247668
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/