Dynamic stem cell heterogeneity
Company of Biologists
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Krieger, T., & Simons, B. (2015). Dynamic stem cell heterogeneity. Development, 142 1396-1406. https://doi.org/10.1242/dev.101063
Recent lineage-tracing studies based on inducible genetic labelling have emphasized a crucial role for stochasticity in the maintenance and regeneration of cycling adult tissues. These studies have revealed that stem cells are frequently lost through differentiation and that this is compensated for by the duplication of neighbours, leading to the consolidation of clonal diversity. Through the combination of long-term lineage-tracing assays with short-term in vivo live imaging, the cellular basis of this stochastic stem cell loss and replacement has begun to be resolved. With a focus on mammalian spermatogenesis, intestinal maintenance and the hair cycle, we review the role of dynamic heterogeneity in the regulation of adult stem cell populations.
Adult stem cell, Gene heterogeneity, Germ line, Intestine, Lineage tracing, Tissue homeostasis
B.D.S. acknowledges the financial support of the Wellcome Trust [098357/Z/12/Z] as well as core grants from the Wellcome Trust  and Cancer Research UK [C6946/A14492].
Wellcome Trust (098357/Z/12/Z)
Wellcome Trust (092096/Z/10/Z)
Cancer Research UK (A14492)
External DOI: https://doi.org/10.1242/dev.101063
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247680