Show simple item record

dc.contributor.authorKrieger, Teresaen
dc.contributor.authorSimons, Benjaminen
dc.date.accessioned2015-05-14T08:07:00Z
dc.date.available2015-05-14T08:07:00Z
dc.date.issued2015-04-15en
dc.identifier.citationDevelopment (2015) 142, 1396-1406 doi:10.1242/dev.101063en
dc.identifier.issn0950-1991
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247680
dc.description.abstractRecent lineage-tracing studies based on inducible genetic labelling have emphasized a crucial role for stochasticity in the maintenance and regeneration of cycling adult tissues. These studies have revealed that stem cells are frequently lost through differentiation and that this is compensated for by the duplication of neighbours, leading to the consolidation of clonal diversity. Through the combination of long-term lineage-tracing assays with short-term in vivo live imaging, the cellular basis of this stochastic stem cell loss and replacement has begun to be resolved. With a focus on mammalian spermatogenesis, intestinal maintenance and the hair cycle, we review the role of dynamic heterogeneity in the regulation of adult stem cell populations.
dc.description.sponsorshipB.D.S. acknowledges the financial support of the Wellcome Trust [098357/Z/12/Z] as well as core grants from the Wellcome Trust [092096] and Cancer Research UK [C6946/A14492].
dc.languageEnglishen
dc.language.isoenen
dc.publisherCompany of Biologists
dc.subjectAdult stem cellen
dc.subjectGene heterogeneityen
dc.subjectGerm lineen
dc.subjectIntestineen
dc.subjectLineage tracingen
dc.subjectTissue homeostasisen
dc.titleDynamic stem cell heterogeneityen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available via The Company of Biologists at http://dev.biologists.org/content/142/8/1396.abstract.en
prism.endingPage1406
prism.publicationDate2015en
prism.publicationNameDevelopmenten
prism.startingPage1396
prism.volume142en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderCRUK
dc.rioxxterms.projectid098357/Z/12/Z
dc.rioxxterms.projectid092096
dc.rioxxterms.projectidC6946/A14492
rioxxterms.versionofrecord10.1242/dev.101063en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-04-15en
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.identifier.eissn1477-9129
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (098357/Z/12/Z)
pubs.funder-project-idEPSRC (EP/F032773/1)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idCancer Research UK (A14492)
rioxxterms.freetoread.startdate2016-04-15


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record