Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
Steer, Philip J
International Journal of Gynecology & Obstetrics
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Oliver-Williams, C., & Steer, P. J. (2015). Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies. International Journal of Gynecology & Obstetrics, 129 207-212. https://doi.org/10.1016/j.ijgo.2015.01.004
Objective: To assess the relationship between race and spontaneous abortion, whether the relationship varies by risk factors, and the effect of spontaneous abortions on subsequent pregnancies. Methods: A retrospective study was undertaken using data collected in London, UK, between 1988 and 2000. Logistic regression evaluated histories of spontaneous abortion and associations with small-for-gestational-age and preterm births in black African, black Caribbean, and South Asian women relative to white European women. Interactions with risk factors were assessed. Results: Overall, 196 040womenwere included. Compared with white Europeans, the odds of a previous spontaneous abortionwere increased in black African (adjusted odds ratio [aOR] 1.20; 95% confidence interval [CI] 1.12–1.29) and black Caribbean women (aOR 1.31; 95% CI 1.21–1.41). The strength of the association with black African race increasedwith age (P=0.002), and the associationwith South Asian race increasedwith age and body mass index (P b 0.001 for both). Spontaneous abortion was associated with preterm birth in all races, but was strongest in black African women (aOR 1.47; 95% CI 1.29–1.67). Conclusion: The greater incidence of spontaneous abortion in black African and black Caribbean women should prompt further study of risk factors in relation to race. The interaction with age in black African and South Asian women could be important for counseling in relation to timing of pregnancy.
Preterm birth, Race, Racial group, Small for gestational age, Spontaneous abortion
This work was supported by a Medical Research Council PhD Studentship.
External DOI: https://doi.org/10.1016/j.ijgo.2015.01.004
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247699
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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