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dc.contributor.authorMoreau, Pierricken
dc.contributor.authorMoreau, Kevinen
dc.contributor.authorSegarra, Amélieen
dc.contributor.authorTourbiez, Delphineen
dc.contributor.authorTravers, Marie-Agnèsen
dc.contributor.authorRubinsztein, Daviden
dc.contributor.authorRenault, Tristanen
dc.date.accessioned2015-05-15T14:56:14Z
dc.date.available2015-05-15T14:56:14Z
dc.date.issued2015-02-25en
dc.identifier.citationAutophagy Volume 11, Issue 3, 2015, 516-526. DOI: 10.1080/15548627.2015.1017188en
dc.identifier.issn1554-8627
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247738
dc.description.abstractRecent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.
dc.description.sponsorshipThis work was partially funded through the EU project Bivalife (FP7 KBBE, contract n 266157), the Poitou Charentes Region and DPMA (Direction des p^eches maritimes et de l’aquaculture, AESTU project). David Rubinsztein is aWellcome Trust Prinicipal Research Fellow.
dc.languageEnglishen
dc.language.isoenen
dc.publisherTaylor & Francis
dc.rightsAttribution-NonCommercial 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/uk/*
dc.subjectautophagyen
dc.subjectCrassostrea gigasen
dc.subjectOsHV-1en
dc.subjectPacific oysteren
dc.subjectVibrio aestuarianusen
dc.subjectATGen
dc.subjectautophagy-relateden
dc.subjectAtg8–PEen
dc.subjectAtg8–phosphatidylethenolamineen
dc.subjectDNAen
dc.subjectdeoxyribonucleic aciden
dc.subjecthpien
dc.subjecthours postinfectionen
dc.subjectLC3-II, cleaved, lipidated and autophagosome-associated form of LC3en
dc.subjectMAP1LC3A/B (LC3A/B), microtubule-associated proteins 1 light chain 3 alpha/beta (mammalian orthologs of the predicted Crassostrea gigas LC3 and yeast Atg8)en
dc.subjectNH4Cl, ammonium chlorideen
dc.subjectOsHV-1, Ostreid herpesvirus 1en
dc.subjectPCR, polymerase chain reactionen
dc.titleAutophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infectionsen
dc.typeArticle
dc.description.versionThis is the final published version. It first appeared at http://www.tandfonline.com/doi/full/10.1080/15548627.2015.1017188.en
prism.endingPage526
prism.publicationDate2015en
prism.publicationNameAutophagyen
prism.startingPage516
prism.volume11en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderEU FP7
dc.rioxxterms.projectid266157
rioxxterms.versionofrecord10.1080/15548627.2015.1017188en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-02-25en
dc.contributor.orcidMoreau, Kevin [0000-0002-3688-3998]
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.identifier.eissn1554-8635
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
pubs.funder-project-idWellcome Trust (095317/Z/11/A)


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Attribution-NonCommercial 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 2.0 UK: England & Wales