Show simple item record

dc.contributor.authorConlan, Andrewen
dc.contributor.authorPollock, Ellen Brooksen
dc.contributor.authorMcKinley, Trevelyan Jen
dc.contributor.authorMitchell, Andrew Pen
dc.contributor.authorJones, Gareth Jen
dc.contributor.authorVordermeier, Martinen
dc.contributor.authorWood, Jamesen
dc.date.accessioned2015-05-18T12:26:06Z
dc.date.available2015-05-18T12:26:06Z
dc.date.issued2015-02-19en
dc.identifier.citationConlan AJK, Brooks Pollock E, McKinley TJ, Mitchell AP, Jones GJ, Vordermeier M, Wood JLN, PLoS Computational Biology 2015, 11(2): e1004038. doi:10.1371/journal.pcbi.1004038en
dc.identifier.issn1553-734X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247758
dc.description.abstractVaccination for the control of bovine tuberculosis (bTB) in cattle is not currently used within any international control program, and is illegal within the EU. Candidate vaccines, based upon Mycobacterium bovis bacillus Calmette-Guérin (BCG) all interfere with the action of the tuberculin skin test, which is used to determine if animals, herds and countries are officially bTB-free. New diagnostic tests that Differentiate Infected from Vaccinated Animals (DIVA) offer the potential to introduce vaccination within existing eradication programs. We use within-herd transmission models estimated from historical data from Great Britain (GB) to explore the feasibility of such supplemental use of vaccination. The economic impact of bovine Tuberculosis for farmers is dominated by the costs associated with testing, and associated restrictions on animal movements. Farmers’ willingness to adopt vaccination will require vaccination to not only reduce the burden of infection, but also the risk of restrictions being imposed. We find that, under the intensive sequence of testing in GB, it is the specificity of the DIVA test, rather than the sensitivity, that is the greatest barrier to see a herd level benefit of vaccination. The potential negative effects of vaccination could be mitigated through relaxation of testing. However, this could potentially increase the hidden burden of infection within Officially TB Free herds. Using our models, we explore the range of the DIVA test characteristics necessary to see a protective herd level benefit of vaccination. We estimate that a DIVA specificity of at least 99.85% and sensitivity of >40% is required to see a protective benefit of vaccination with no increase in the risk of missed infection. Data from experimentally infected animals suggest that this target specificity could be achieved in vaccinates using a cocktail of three DIVA antigens while maintaining a sensitivity of 73.3% (95%CI: 61.9, 82.9%) relative to post-mortem detection.
dc.description.sponsorshipThis study was funded by Defra project SE3127 and uses nationally collected incidence and cattle-movement data sets held by Defra. The funders had no role in study design, data analysis, decision to publish, or preparation of the manuscript.
dc.languageEnglishen
dc.language.isoenen
dc.publisherPLOS
dc.titlePotential Benefits of Cattle Vaccination as a Supplementary Control for Bovine Tuberculosisen
dc.typeArticle
dc.description.versionThis is the final published version of the article. It was originally published in PLOS Computational Biology (Conlan AJK, Brooks Pollock E, McKinley TJ, Mitchell AP, Jones GJ, Vordermeier M, Wood JLN, PLoS Computational Biology 2015, 11(2): e1004038. doi:10.1371/journal.pcbi.1004038). © 2015 Crown Copyright. This is an open-access article distributed under the terms of the free Open Government Licence, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. See: http://www.nationalarchives.gov.uk/doc/o​pen-government-licence/open-government-l​icence.htmen
prism.number2en
prism.publicationDate2015en
prism.publicationNamePLOS Computational Biologyen
prism.startingPagee1004038
prism.volume11en
dc.rioxxterms.funderDefra
dc.rioxxterms.projectidSE3127
dcterms.dateAccepted2014-11-12en
rioxxterms.versionofrecord10.1371/journal.pcbi.1004038en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-02-19en
dc.contributor.orcidConlan, Andrew [0000-0002-2593-6353]
dc.contributor.orcidWood, James [0000-0002-0258-3188]
dc.identifier.eissn1553-7358
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/H027270/1)
pubs.funder-project-idDepartment for Environment, Food and Rural Affairs (Defra) (SE3127)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record