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dc.contributor.authorEriksen, Anneen
dc.contributor.authorTillin, Thereseen
dc.contributor.authorO’Connor, Lauraen
dc.contributor.authorBrage, Sorenen
dc.contributor.authorHughes, Alunen
dc.contributor.authorMayet, Jamilen
dc.contributor.authorMcKeigue, Paulen
dc.contributor.authorWhincup, Peteren
dc.contributor.authorChaturvedi, Nishen
dc.contributor.authorForouhi, Nitaen
dc.date.accessioned2015-05-18T12:39:37Z
dc.date.available2015-05-18T12:39:37Z
dc.date.issued2015-03-02en
dc.identifier.citationPLoS ONE 10(3): e0117364. doi:10.1371/journal. pone.0117364en
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247759
dc.description.abstractBackground: There is consistent evidence on the impact of health behaviours on risk of cardiovascular disease (CVD) in European populations. As South Asians in the UK have an excess risk of CVD and coronary heart disease (CHD) compared to Europeans, we investigated whether a similar association between combined health behaviours and risk of CVD and CHD among this high-risk group exists, and estimated the population impact. Methods and Findings: In a prospective cohort of 1090 Europeans and 1006 South Asians (40–69 y) without prevalent CVD at baseline (1988–1990), followed up for 21 years to 2011, there were 601 incident CVD events [Europeans n = 255; South Asians n = 346] of which 520 were CHD events [n = 207 and 313 respectively]. Participants scored between 0 to 4 points for a composite score including four baseline healthy behaviours (non-smoker, moderate alcohol intake, physically active, frequent fruit/vegetable intake). Adjusted hazard ratios (95% confidence intervals) for incident CHD in Europeans who had three, two, one, and zero compared to four health behaviours were 1.33 (0.78–2.29), 1.96 (1.15–3.33), 1.36 (0.74–2.48) and 2.45 (1.18–5.10), respectively, p-trend = 0.025. In South Asians, corresponding HRs were 2.88 (1.33–6.24), 2.28 (1.06–4.91), 3.36 (1.53–7.39) and 3.48 (1.38–8.81), p-trend = 0.022. The results were similar for incident CVD; Europeans HR 2.12 (1.14–3.94), p–trend = 0.014; South Asians HR 2.73 (1.20–6.21), p-trend = 0.018. The population attributable fraction in Europeans was 43% for CHD and 28% for CVD. In South Asians it was 63% and 51% respectively. Conclusions: Lack of adherence to four combined health behaviours was associated with 2 to 3-fold increased risk of incident CVD in Europeans and South Asians. A substantial population impact in the South Asian group indicates important potential for disease prevention in this high-risk group by adherence to healthy behaviours.
dc.description.sponsorshipThe SABRE study was funded by the Wellcome Trust (082464/Z/07/Z) and British Heart Foundation (SP/07/001/23603). Support from NIHR Biomedical Research Centre funding scheme as well as the MRC Epidemiology Unit (MC_UU_12015/5 to NGF) is acknowledged.
dc.languageEnglishen
dc.language.isoenen
dc.publisherPLOS
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectBehavioral and social aspects of healthen
dc.subjectCardiovascular diseasesen
dc.subjectEthnic epidemiologyen
dc.subjectAlcohol consumptionen
dc.subjectCholesterolen
dc.subjectBlood pressureen
dc.subjectEthnic groupsen
dc.subjectCoronary heart diseaseen
dc.titleThe impact of health behaviours on incident cardiovascular disease in Europeans and South Asians – a prospective analysis in the UK SABRE studyen
dc.typeArticle
dc.description.versionThis is the final published version. It first appeared at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117364#ack.en
prism.numbere011736en
prism.publicationDate2015en
prism.publicationNamePLoS ONEen
prism.volume10en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderBHF
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderMRC
dc.rioxxterms.projectid082464/Z/07/Z
dc.rioxxterms.projectidSP/07/001/2360
dc.rioxxterms.projectidMC_UU_12015/5
dcterms.dateAccepted2014-12-23en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-03-02en
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/3)
pubs.funder-project-idMRC (MC_UU_12015/5)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales