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dc.contributor.authorMichailidou, Kyriakien
dc.contributor.authorBeesley, Jonathanen
dc.contributor.authorLindstrom, Saraen
dc.contributor.authorCanisius, Sanderen
dc.contributor.authorDennis, Joeen
dc.contributor.authorLush, Michael Jen
dc.contributor.authorMaranian, Mel Jen
dc.contributor.authorBolla, Manjeet Ken
dc.contributor.authorWang, Qinen
dc.contributor.authorShah, Mitulkumar Nandlalen
dc.contributor.authorPerkins, Barbara Jen
dc.contributor.authorCzene, Kamilaen
dc.contributor.authorEriksson, Mikaelen
dc.contributor.authorDarabi, Hatefen
dc.contributor.authorBrand, Judith Sen
dc.contributor.authorBojesen, Stig Een
dc.contributor.authorNordestgaard, Borge Gen
dc.contributor.authorFlyger, Henriken
dc.contributor.authorNielsen, Sune Fen
dc.contributor.authorRahman, Nazneenen
dc.contributor.authorTurnbull, Clareen
dc.contributor.authorBOCS,en
dc.contributor.authorFletcher, Oliviaen
dc.contributor.authorPeto, Julianen
dc.contributor.authorGibson, Lornaen
dc.contributor.authordos-Santos-Silva, Isabelen
dc.contributor.authorChang-Claude, Jennyen
dc.contributor.authorFlesch-Janys, Dieteren
dc.contributor.authorRudolph, Anjaen
dc.contributor.authorEilber, Ursulaen
dc.contributor.authorBehrens, Sabineen
dc.contributor.authorNevanlinna, Helien
dc.contributor.authorMuranen, Taru Aen
dc.contributor.authorAittomaki, Kristiinaen
dc.contributor.authorBlomqvist, Carlen
dc.contributor.authorKhan, Sofiaen
dc.contributor.authorAaltonen, Kirsimarien
dc.contributor.authorAhsan, Habibulen
dc.contributor.authorKibriya, Muhammad Gen
dc.contributor.authorWhittemore, Alice Sen
dc.contributor.authorJohn, Esther Men
dc.contributor.authorMalone, Kathleen Een
dc.contributor.authorGammon, Marilie Den
dc.contributor.authorSantella, Regina Men
dc.contributor.authorUrsin, Giskeen
dc.contributor.authorMakalic, Enesen
dc.contributor.authorSchmidt, Daniel Fen
dc.contributor.authorCasey, Grahamen
dc.contributor.authorHunter, David Jen
dc.contributor.authorGapstur, Susan Men
dc.contributor.authorGaudet, Mia Men
dc.contributor.authorDiver, W Ryanen
dc.contributor.authorHaiman, Christopher Aen
dc.contributor.authorSchumacher, Fredricken
dc.contributor.authorHenderson, Brian Een
dc.contributor.authorLe, Marchand Loicen
dc.contributor.authorBerg, Christine Den
dc.contributor.authorChanock, Stephen Jen
dc.contributor.authorFigueroa, Jonineen
dc.contributor.authorHoover, Robert Nen
dc.contributor.authorLambrechts, Dietheren
dc.contributor.authorNeven, Patricken
dc.contributor.authorWildiers, Hansen
dc.contributor.authorvan, Limbergen Eriken
dc.contributor.authorSchmidt, Marjanka Ken
dc.contributor.authorBroeks, Annegienen
dc.contributor.authorVerhoef, Sennoen
dc.contributor.authorCornelissen, Stenen
dc.contributor.authorCouch, Fergus Jen
dc.contributor.authorOlson, Janet Een
dc.contributor.authorHallberg, Emilyen
dc.contributor.authorVachon, Celineen
dc.contributor.authorWaisfisz, Quintenen
dc.contributor.authorMeijers-Heijboer, Hanneen
dc.contributor.authorAdank, Muriel Aen
dc.contributor.authorvan, der Luijt Rob Ben
dc.contributor.authorLi, Jingmeien
dc.contributor.authorLiu, Jianjunen
dc.contributor.authorHumphreys, Keithen
dc.contributor.authorKang, Daeheeen
dc.contributor.authorChoi, Ji-Yeoben
dc.contributor.authorPark, Sue Ken
dc.contributor.authorYoo, Keun-Youngen
dc.contributor.authorMatsuo, Keitaroen
dc.contributor.authorIto, Hidemien
dc.contributor.authorIwata, Hirojien
dc.contributor.authorTajima, Kazuoen
dc.contributor.authorGuenel, Pascalen
dc.contributor.authorTruong, Thereseen
dc.contributor.authorMulot, Claireen
dc.contributor.authorSanchez, Marieen
dc.contributor.authorBurwinkel, Barbaraen
dc.contributor.authorMarme, Frederiken
dc.contributor.authorSurowy, Haralden
dc.contributor.authorSohn, Christofen
dc.contributor.authorWu, Anna Hen
dc.contributor.authorTseng, Chiu-chenen
dc.contributor.authorVan, Den Berg Daviden
dc.contributor.authorStram, Daniel Oen
dc.contributor.authorGonzalez-Neira, Annaen
dc.contributor.authorBenitez, Javieren
dc.contributor.authorZamora, M Pilaren
dc.contributor.authorPerez, Jose Ignacio Ariasen
dc.contributor.authorShu, Xiao-Ouen
dc.contributor.authorLu, Weien
dc.contributor.authorGao, Yu-Tangen
dc.contributor.authorCai, Huien
dc.contributor.authorCox, Angelaen
dc.contributor.authorCross, Simon Sen
dc.contributor.authorReed, Malcolm WRen
dc.contributor.authorAndrulis, Irene Len
dc.contributor.authorKnight, Julia Aen
dc.contributor.authorGlendon, Gorden
dc.contributor.authorMulligan, Anna Marieen
dc.contributor.authorSawyer, Elinor Jen
dc.contributor.authorTomlinson, Ianen
dc.contributor.authorKerin, Michael Jen
dc.contributor.authorMiller, Nicolaen
dc.contributor.authorkConFab, Investigatorsen
dc.contributor.authorAOCS, Groupen
dc.contributor.authorLindblom, Annikaen
dc.contributor.authorMargolin, Saraen
dc.contributor.authorTeo, Soo Hwangen
dc.contributor.authorYip, Cheng Haren
dc.contributor.authorTaib, Nur Aishah Mohden
dc.contributor.authorTan, Gie-Hooien
dc.contributor.authorHooning, Maartje Jen
dc.contributor.authorHollestelle, Antoinetteen
dc.contributor.authorMartens, John WMen
dc.contributor.authorCollee, J Margrieten
dc.contributor.authorBlot, Williamen
dc.contributor.authorSignorello, Lisa Ben
dc.contributor.authorCai, Qiuyinen
dc.contributor.authorHopper, John Len
dc.contributor.authorSouthey, Melissa Cen
dc.contributor.authorTsimiklis, Helenen
dc.contributor.authorApicella, Carmelen
dc.contributor.authorShen, Chen-Yangen
dc.contributor.authorHsiung, Chia-Nien
dc.contributor.authorWu, Pei-Eien
dc.contributor.authorHou, Ming-Fengen
dc.contributor.authorKristensen, Vessela Nen
dc.contributor.authorNord, Siljeen
dc.contributor.authorAlnaes, Grethe I Grenakeren
dc.contributor.authorNBCS,en
dc.contributor.authorGiles, Graham Gen
dc.contributor.authorMilne, Roger Len
dc.contributor.authorMcLean, Catrionaen
dc.contributor.authorCanzian, Federicoen
dc.contributor.authorTrichopoulos, Dimitriosen
dc.contributor.authorPeeters, Petraen
dc.contributor.authorLund, Eiliven
dc.contributor.authorSund, Malinen
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorGunter, Marc Jen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorMortensen, Lotte Maxilden
dc.contributor.authorDossus, Laureen
dc.contributor.authorHuerta, Jose-Mariaen
dc.contributor.authorMeindl, Alfonsen
dc.contributor.authorSchmutzler, Rita Ken
dc.contributor.authorSutter, Christianen
dc.contributor.authorYang, Rongxien
dc.contributor.authorMuir, Kennethen
dc.contributor.authorLophatananon, Artitayaen
dc.contributor.authorStewart-Brown, Sarahen
dc.contributor.authorSiriwanarangsan, Pornthepen
dc.contributor.authorHartman, Mikaelen
dc.contributor.authorMiao, Huien
dc.contributor.authorChia, Kee Sengen
dc.contributor.authorChan, Ching Wanen
dc.contributor.authorFasching, Peter Aen
dc.contributor.authorHein, Alexanderen
dc.contributor.authorBeckmann, Matthias Wen
dc.contributor.authorHaeberle, Lotharen
dc.contributor.authorBrenner, Hermannen
dc.contributor.authorDieffenbach, Aida Karinaen
dc.contributor.authorArndt, Volkeren
dc.contributor.authorStegmaier, Christaen
dc.contributor.authorAshworth, Alanen
dc.contributor.authorOrr, Nicken
dc.contributor.authorSchoemaker, Minouk Jen
dc.contributor.authorSwerdlow, Anthony Jen
dc.contributor.authorBrinton, Louiseen
dc.contributor.authorGarcia-Closas, Montserraten
dc.contributor.authorZheng, Weien
dc.contributor.authorHalverson, Sandra Len
dc.contributor.authorShrubsole, Marthaen
dc.contributor.authorLong, Jirongen
dc.contributor.authorGoldberg, Mark Sen
dc.contributor.authorLabreche, Franceen
dc.contributor.authorDumont, Martineen
dc.contributor.authorWinqvist, Roberten
dc.contributor.authorPylkas, Katrien
dc.contributor.authorJukkola-Vuorinen, Arjaen
dc.contributor.authorGrip, Mervien
dc.contributor.authorBrauch, Hiltruden
dc.contributor.authorHamann, Uteen
dc.contributor.authorBruning, Thomasen
dc.contributor.authorGENICA, Networken
dc.contributor.authorRadice, Paoloen
dc.contributor.authorPeterlongo, Paoloen
dc.contributor.authorManoukian, Siranoushen
dc.contributor.authorBernard, Lorisen
dc.contributor.authorBogdanova, Natalia Ven
dc.contributor.authorDork, Thiloen
dc.contributor.authorMannermaa, Artoen
dc.contributor.authorKataja, Vesaen
dc.contributor.authorKosma, Veli-Mattien
dc.contributor.authorHartikainen, Jaana Men
dc.contributor.authorDevilee, Peteren
dc.contributor.authorTollenaar, Robert AEMen
dc.contributor.authorSeynaeve, Carolineen
dc.contributor.authorVan, Asperen Christi Jen
dc.contributor.authorJakubowska, Annaen
dc.contributor.authorLubinski, Janen
dc.contributor.authorJaworska, Katarzynaen
dc.contributor.authorHuzarski, Tomaszen
dc.contributor.authorSangrajrang, Suleepornen
dc.contributor.authorGaborieau, Valerieen
dc.contributor.authorBrennan, Paulen
dc.contributor.authorMcKay, Jamesen
dc.contributor.authorSlager, Susanen
dc.contributor.authorToland, Amanda Een
dc.contributor.authorAmbrosone, Christine Ben
dc.contributor.authorYannoukakos, Drakoulisen
dc.contributor.authorKabisch, Mariaen
dc.contributor.authorTorres, Dianaen
dc.contributor.authorNeuhausen, Susan Len
dc.contributor.authorAnton-Culver, Hodaen
dc.contributor.authorLuccarini, Craigen
dc.contributor.authorBaynes, Carolineen
dc.contributor.authorAhmed, Shahanaen
dc.contributor.authorHealey, Catherine Sen
dc.contributor.authorTessier, Daniel Cen
dc.contributor.authorVincent, Danielen
dc.contributor.authorBacot, Francoisen
dc.contributor.authorPita, Guillermoen
dc.contributor.authorAlonso, M Rosarioen
dc.contributor.authorAlvarez, Nuriaen
dc.contributor.authorHerrero, Danielen
dc.contributor.authorSimard, Jacquesen
dc.contributor.authorPharoah, Paul Daviden
dc.contributor.authorKraft, Peteren
dc.contributor.authorDunning, Alison Margareten
dc.contributor.authorChenevix-Trench, Georgiaen
dc.contributor.authorHall, Peren
dc.contributor.authorEaston, Douglas Fredericken
dc.date.accessioned2015-05-19T14:50:31Z
dc.date.available2015-05-19T14:50:31Z
dc.date.issued2015-03-09en
dc.identifier.citationMichailidou et al Nature Genetics 2015 Apr; 47(4), 373-80. DOI: 10.1038/ng.3242en
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247820
dc.description.abstractGenome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10−8. Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
dc.description.sponsorshipBCAC is funded by Cancer Research UK (C1287/A10118, C1287/A12014) and by the European Community's Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175) (COGS). Meetings of the BCAC have been funded by the European Union COST programme (BM0606). Genotyping on the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710, C8197/A16565), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer program and the Ministry of Economic Development, Innovation and Export Trade of Quebec, grant PSR-SIIRI-701. Combination of the GWAS data was supported in part by the US National Institutes of Health (NIH) Cancer Post-Cancer GWAS initiative, grant 1 U19 CA148065-01 (DRIVE, part of the GAME-ON initiative). For a full description of funding and acknowledgments, see the Supplementary Note.
dc.languageEnglishen
dc.language.isoenen
dc.publisherNPG
dc.titleGenome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.en
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ng.3242en
prism.endingPage380
prism.publicationDate2015en
prism.publicationNameNature Geneticsen
prism.startingPage373
prism.volume47en
dc.rioxxterms.funderCRUK
dc.rioxxterms.projectidC1287/A10118
dc.rioxxterms.projectidC1287/A12014
dc.rioxxterms.projectidC1287/A10710
dc.rioxxterms.projectidC8197/A16565
dcterms.dateAccepted2015-02-11en
rioxxterms.versionofrecord10.1038/ng.3242en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-03-09en
dc.contributor.orcidWang, Qin [0000-0002-9139-0627]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.contributor.orcidPharoah, Paul David [0000-0001-8494-732X]
dc.contributor.orcidDunning, Alison Margaret [0000-0001-6651-7166]
dc.contributor.orcidEaston, Douglas Frederick [0000-0003-2444-3247]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research UK (16565)
pubs.funder-project-idEuropean Commission (223175)
pubs.funder-project-idNational Cancer Institute (U19CA148065)
rioxxterms.freetoread.startdate2015-09-09


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