Switching Roles: The functional plasticity of adult tissue stem cells
The EMBO Journal
MetadataShow full item record
Wabik, A., & Jones, P. (2015). Switching Roles: The functional plasticity of adult tissue stem cells. The EMBO Journal, 34 1164-1179. https://doi.org/10.15252/embj.201490386
Adult organisms have to adapt to survive, and the same is true for their tissues. Rates and types of cell production must be rapidly and reversibly adjusted to meet tissue demands in response to both local and systemic challenges. Recent work reveals how stem cell (SC) populations meet these requirements by switching between functional states tuned to homeostasis or regeneration. This plasticity extends to differentiating cells, which are capable of reverting to SC after injury. The concept of the niche, the micro-environment that sustains and regulates stem cells, is broadening, with a new appreciation of the role of physical factors and hormonal signals. Here we review different functions of SC, the cellular mechanisms that underlie them and the signals that bias SC fate as they switch between roles.
Stem cells, Niche, Differentiation, Regeneration, Signal transduction
We thank J. Fowler, J. Frede, P. Greulich, A.M. Klein, K. Murai, B.D. Simons and D.J. Winton for discussions. We acknowledge the support of the Medical Research Council, the Wellcome Trust (Project grant WT090334MA, P.H.J. and PhD studentship Programme in Stem Cell Biology & Medicine, A.W.) and Cancer Research UK (Programme Grant C609/A17257, P.H.J.).
Medical Research Council (MC_UU_12022/3)
Cancer Research UK (C609/A17257)
External DOI: https://doi.org/10.15252/embj.201490386
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247821