Two-stage directed self-assembly of a cyclic catenane
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Wood, C. S., Ronson, T., Belenguer, A., Holstein, J. J., & Nitschke, J. (2015). Two-stage directed self-assembly of a cyclic catenane. Nature Chemistry, 7 354-358. https://doi.org/10.1038/nchem.2205
Interlocked molecules possess properties and functions that depend upon their intricate connectivity. In addition to the topologically trivial rotaxanes, whose structures may be captured by a planar graph, the topologically non-trivial knots and catenanes represent some of chemistry's most challenging synthetic targets because of the three-dimensional assembly necessary for their construction. Here we report the synthesis of a cyclic catenane, which consists of three mutually interpenetrating rings, via an unusual synthetic route. Five distinct building blocks self-assemble into a heteroleptic triangular framework composed of two joined FeII3L3 circular helicates. Subcomponent exchange then enables specific points in the framework to be linked together to generate the cyclic catenane product. Our method represents an advance both in the intricacy of the metal-templated self-assembly procedure and in the use of selective imine exchange to generate a topologically complex product.
This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC) and a Marie Curie fellowship for J.J.H. (ITN-2010–264645). The authors thank the Diamond Light Source (UK) for synchrotron beamtime on I19 (MT7984 and MT8464).
European Commission (264645)
External DOI: https://doi.org/10.1038/nchem.2205
This record's URL: https://www.repository.cam.ac.uk/handle/1810/247840