Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory.
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Authors
Ashworth, Jennifer C
Mehr, Marco
Buxton, Paul G
Best, Serena M
Cameron, Ruth E
Abstract
The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.
Description
Keywords
cell invasion, collagen scaffolds, interconnectivity, percolation, scaffold characterization, Cell Movement, Cells, Cultured, Collagen, Fibroblasts, Humans, Models, Biological, Tissue Scaffolds, X-Ray Microtomography
Journal Title
Adv Healthc Mater
Conference Name
Journal ISSN
2192-2640
2192-2659
2192-2659
Volume Title
4
Publisher
Wiley-VCH Verlag
Publisher DOI
Sponsorship
European Research Council (320598)
The authors acknowledge financial support from EPSRC, Geistlich Pharma AG and ERC Advanced Grant 320598 3D-E.