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Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory.


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Authors

Ashworth, Jennifer C 
Mehr, Marco 
Buxton, Paul G 
Best, Serena M 
Cameron, Ruth E 

Abstract

The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.

Description

Keywords

cell invasion, collagen scaffolds, interconnectivity, percolation, scaffold characterization, Cell Movement, Cells, Cultured, Collagen, Fibroblasts, Humans, Models, Biological, Tissue Scaffolds, X-Ray Microtomography

Journal Title

Adv Healthc Mater

Conference Name

Journal ISSN

2192-2640
2192-2659

Volume Title

4

Publisher

Wiley-VCH Verlag
Sponsorship
European Research Council (320598)
The authors acknowledge financial support from EPSRC, Geistlich Pharma AG and ERC Advanced Grant 320598 3D-E.