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dc.contributor.authorPoole, Emmaen
dc.contributor.authorJuss, Jatinder Ken
dc.contributor.authorKrishna, Benjaminen
dc.contributor.authorHerre, Jurgenen
dc.contributor.authorChilvers, Edwinen
dc.contributor.authorSinclair, Johnen
dc.date.accessioned2015-06-01T10:47:57Z
dc.date.available2015-06-01T10:47:57Z
dc.date.issued2014-12-30en
dc.identifier.citationJournal of Infectious Diseases (2015) 211 (12): 1936-1942. DOI: 10.1093/infdis/jiu837en
dc.identifier.issn0022-1899
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248117
dc.description.abstractHuman cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in progenitor cells of the myeloid lineage. These cells exhibit limited viral gene transcription and no evidence of de novo virion production. It is well recognized that differentiation of latently infected myeloid progenitor cells to dendritic or macrophage-like cells permits viral reactivation in vitro. This has been used to support the concept that viral reactivation in HCMV carriers routinely occurs from such terminally differentiated myeloid cells in vivo. However, to date this has not been shown for in vivo– differentiated macrophages. This study is the first to demonstrate that alveolar macrophages from HCMV carriers express immediate early lytic genes and produce infectious virus. This supports the view, until now based on in vitro data, that terminally differentiated myeloid cells in vivo are sites of HCMV reactivation and potential centers of viral dissemination in latently infected individuals with no evidence of virus disease or dissemination.
dc.description.sponsorshipThis work was supported by the UK Medical Research Council (grant 0701279 to J. S.) and the National Institute for Health Research UK Biomedical Research Centre (to J. S. and E. R. C.).
dc.languageEnglishen
dc.language.isoenen
dc.publisherOxford Journals on behalf of the Infectious Diseases Society of America and the HIV Medicine Association
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjecthuman cytomegalovirusen
dc.subjectmacrophagesen
dc.subjectreactivationen
dc.titleAlveolar macrophages isolated directly from human cytomegalovirus (HCMV) seropositive individuals are sites of HCMV reactivation in vivoen
dc.typeArticle
dc.description.versionThis is the final published version. It first appeared at http://jid.oxfordjournals.org/content/211/12/1936.en
prism.endingPage1942
prism.publicationDate2014en
prism.publicationNameJournal of Infectious Diseasesen
prism.startingPage1936
prism.volume211en
dc.rioxxterms.funderMRC
dc.rioxxterms.projectid0701279
dcterms.dateAccepted2014-12-15en
rioxxterms.versionofrecord10.1093/infdis/jiu837en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-12-30en
dc.contributor.orcidPoole, Emma [0000-0003-3904-6121]
dc.contributor.orcidChilvers, Edwin [0000-0002-4230-9677]
dc.contributor.orcidSinclair, John [0000-0002-2616-9571]
dc.identifier.eissn1537-6613
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/K021087/1)
pubs.funder-project-idMRC (G0701279)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales