Suppression of inflammation by helminths - a role for the gut microbiota?
Philosophical Transactions of the Royal Society B
Royal Society Publishing
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Giacomin, P., Croese, J., Krause, L., Loukas, A., & Cantacessi, C. (2015). Suppression of inflammation by helminths - a role for the gut microbiota?. Philosophical Transactions of the Royal Society B, 370 (20140296)https://doi.org/10.1098/rstb.2014.0296
Multiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of the host-parasite-microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis on the role of the gut microbiota in helminth-induced suppression of inflammation.
Microbiota, Host-parasite interactions, Helminth-induced suppression of inflammation, Hookworms, Whipworms, Microbial richness
Funding from the Isaac Newton Trust / Wellcome Trust ISSF / University of Cambridge Joint Research Grants Scheme (C.C.) and the Australian National Health and Medical Research Council (NHMRC) grants 1037304, 1020114 (A.L.), 1052938 (C.C.) and 613718 (P.G.) is gratefully acknowledged.
External DOI: https://doi.org/10.1098/rstb.2014.0296
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248125
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/