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dc.contributor.authorGiacomin, Paulen
dc.contributor.authorCroese, Johnen
dc.contributor.authorKrause, Lutzen
dc.contributor.authorLoukas, Alexen
dc.contributor.authorCantacessi, Cinziaen
dc.date.accessioned2015-06-01T12:37:56Z
dc.date.available2015-06-01T12:37:56Z
dc.date.issued2015-06-01en
dc.identifier.citationGiacomin et al. Philosophical Transactions of the Royal Society B (20150 Vol. 370, 20140296. doi: 10.1098/rstb.2014.0296
dc.identifier.issn0962-8436
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248125
dc.description.abstractMultiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of the host-parasite-microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis on the role of the gut microbiota in helminth-induced suppression of inflammation.
dc.description.sponsorshipFunding from the Isaac Newton Trust / Wellcome Trust ISSF / University of Cambridge Joint Research Grants Scheme (C.C.) and the Australian National Health and Medical Research Council (NHMRC) grants 1037304, 1020114 (A.L.), 1052938 (C.C.) and 613718 (P.G.) is gratefully acknowledged.
dc.languageEnglishen
dc.language.isoenen
dc.publisherRoyal Society Publishing
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectMicrobiotaen
dc.subjectHost-parasite interactionsen
dc.subjectHelminth-induced suppression of inflammationen
dc.subjectHookwormsen
dc.subjectWhipwormsen
dc.subjectMicrobial richnessen
dc.titleSuppression of inflammation by helminths - a role for the gut microbiota?en
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Royal Society Publishing via http://dx.doi.org/10.1098/rstb.2014.0296en
prism.number20140296en
prism.publicationDate2015en
prism.publicationNamePhilosophical Transactions of the Royal Society Ben
prism.volume370en
dc.rioxxterms.funderWellcome Trust
rioxxterms.versionofrecord10.1098/rstb.2014.0296en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-06-01en
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn1471-2970
rioxxterms.typeJournal Article/Reviewen


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales