Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung
Peters, Michael A
British Medical Journal
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Loutsios, C., Farahi, N., Simmonds, R., Cullum, I., Gillett, D., Solanki, C., Solanki, K., et al. (2015). Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung. Thorax, 70 1085-1086. https://doi.org/10.1136/thoraxjnl-2015-207156
The detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to Single Photon Computed Tomography (SPECT)-CT has been demonstrated to localise eosinophilic inflammation in the lungs of a patient with ANCA-positive vasculitis. Here we report on the utility of this technique to detect active eosinophilic inflammation in a patient with focal lung inflammation where a biopsy was contraindicated.
Eosinophil Biology, Pulmonary eosinophilia, Inflammation, Imaging/CT MRI, technetium-99m, SPECT
The authors thank all the staff at the Department of Nuclear Medicine at Addenbrooke’s Hospital and the Wellcome Trust Clinical Research Facility, Cambridge; Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory; and the National Institute for Health Research, through the Comprehensive Clinical Research Network. This work was supported by Asthma-UK [08/11], the Medical Research Council [grant number MR/J00345X/1], the Wellcome Trust [grant number 098351/Z/12/Z], and Cambridge NIHR Biomedical Research Centre. Written informed consent was obtained in accordance with the Declaration of Helsinki. The study was approved by Cambridgeshire Research Ethics Committee (09/H0308/119) and the Administration of Radioactive Substances Advisory Committee of the United Kingdom (83/3130/25000).
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
External DOI: https://doi.org/10.1136/thoraxjnl-2015-207156
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248185