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dc.contributor.authorLoutsios, Chrystallaen
dc.contributor.authorFarahi, Nedaen
dc.contributor.authorSimmonds, Rosalinden
dc.contributor.authorCullum, Ianen
dc.contributor.authorGillett, Danielen
dc.contributor.authorSolanki, Chandraen
dc.contributor.authorSolanki, Kishoren
dc.contributor.authorBuscombe, Johnen
dc.contributor.authorCondliffe, Alisonen
dc.contributor.authorPeters, Michael Aen
dc.contributor.authorChilvers, Edwinen
dc.date.accessioned2015-06-03T08:28:00Z
dc.date.available2015-06-03T08:28:00Z
dc.date.issued2015-06-03en
dc.identifier.citationThorax 2015, 70: 1085-1086. doi:10.1136/thoraxjnl-2015-207156
dc.identifier.issn0040-6376
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248185
dc.description.abstractThe detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to Single Photon Computed Tomography (SPECT)-CT has been demonstrated to localise eosinophilic inflammation in the lungs of a patient with ANCA-positive vasculitis. Here we report on the utility of this technique to detect active eosinophilic inflammation in a patient with focal lung inflammation where a biopsy was contraindicated.
dc.description.sponsorshipThe authors thank all the staff at the Department of Nuclear Medicine at Addenbrooke’s Hospital and the Wellcome Trust Clinical Research Facility, Cambridge; Cambridge Biomedical Research Centre Core Biochemistry Assay Laboratory; and the National Institute for Health Research, through the Comprehensive Clinical Research Network. This work was supported by Asthma-UK [08/11], the Medical Research Council [grant number MR/J00345X/1], the Wellcome Trust [grant number 098351/Z/12/Z], and Cambridge NIHR Biomedical Research Centre. Written informed consent was obtained in accordance with the Declaration of Helsinki. The study was approved by Cambridgeshire Research Ethics Committee (09/H0308/119) and the Administration of Radioactive Substances Advisory Committee of the United Kingdom (83/3130/25000).
dc.languageEnglishen
dc.language.isoenen
dc.publisherBritish Medical Journal
dc.rightsAttribution 2.0 UK: England & Wales
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEosinophil Biologyen
dc.subjectPulmonary eosinophiliaen
dc.subjectInflammationen
dc.subjectImaging/CT MRIen
dc.subjecttechnetium-99men
dc.subjectSPECTen
dc.titleClinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lungen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from the British Medical Journal via http://dx.doi.org/10.1136/thoraxjnl-2015-207156en
prism.endingPage1086
prism.publicationDate2015en
prism.publicationNameThoraxen
prism.startingPage1085
prism.volume70en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidMR/J00345X/1
dc.rioxxterms.projectid098351/Z/12/Z
dcterms.dateAccepted2015-04-16en
rioxxterms.versionofrecord10.1136/thoraxjnl-2015-207156en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-06-03en
dc.contributor.orcidChilvers, Edwin [0000-0002-4230-9677]
dc.identifier.eissn1468-3296
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/J00345X/1)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales