A versatile room temperature route to di- and tri-substituted allenes via flow generated diazo compounds

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Authors
Poh, Jian-Siang
Tran, Duc N
Battilocchio, Claudio
Hawkins, Joel M
  Ley, Steven
Publication Date
2015-05-26
Journal Title
Angewandte Chemie International Edition (English)
ISSN
0044-8249
Publisher
Wiley
Volume
127
Pages
8031-8034
Language
English
Type
Article
Metadata
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Citation
Poh, J., Tran, D. N., Battilocchio, C., Hawkins, J. M., & Ley, S. (2015). A versatile room temperature route to di- and tri-substituted allenes via flow generated diazo compounds. Angewandte Chemie International Edition (English), 127 8031-8034. https://doi.org/10.1002/ange.201501538
Abstract
A copper-catalysed coupling reaction between flow generated unstabilised diazo compounds and terminal alkynes providing di- and tri-substituted allenes is reported. This extremely mild and rapid transformation is highly tolerant of several functional groups.
Keywords
Allene, Carbene, Diazoverbindungen, Durchflusschemie, Kupfer
Sponsorship
We are grateful to the Cambridge Home and European Scholarship Scheme (JSP), Swiss National Science Foundation (DNT), Pfizer Worldwide Research and Development (CB and JMH) and EPSRC (SVL, grant nº EP/K0099494/1 and nº EP/K039520/1) for financial support.
Funder references
EPSRC (EP/K039520/1)
Identifiers
External DOI: https://doi.org/10.1002/ange.201501538
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248205

Rights
Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/

Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales