Machine Assisted Organic Synthesis
Angewandte Chemie International Edition (English)
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Ley, S., Fitzpatrick, D., Myers, R., Battilocchio, C., & Ingham, R. J. (2015). Machine Assisted Organic Synthesis. Angewandte Chemie International Edition (English), 54 3449-3464. https://doi.org/10.1002/anie.201410744
For this new review we describe how the advent of machines is impacting on organic synthesis programs with particular emphasis on the practical issues associated with chemical reactor design. In the rapidly changing, multi-variant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases and organometallics. Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods. All of these areas create both opportunities and challenges during adoption as enabling technologies.
organic methodology, sustainable chemistry, machine-assisted synthesis
The authors gratefully acknowledge support from UK Engineering and Physical Sciences Research Council (SVL and RMM), Woolf Fisher Trust (DEF) and Pfizer Worldwide Research and Development (CB, RJI).
External DOI: https://doi.org/10.1002/anie.201410744
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248221