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dc.contributor.authorLey, Stevenen
dc.contributor.authorFitzpatrick, Danielen
dc.contributor.authorMyers, Rebeccaen
dc.contributor.authorBattilocchio, Claudioen
dc.contributor.authorIngham, Richard Jen
dc.date.accessioned2015-06-03T13:50:56Z
dc.date.available2015-06-03T13:50:56Z
dc.date.issued2015en
dc.identifier.citationAngewandte Chemie International Edition (English) Volume 54, Issue 11, pages 3449–3464, March 9, 2015. DOI: 10.1002/anie.201410744en
dc.identifier.issn1433-7851
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248221
dc.description.abstractFor this new review we describe how the advent of machines is impacting on organic synthesis programs with particular emphasis on the practical issues associated with chemical reactor design. In the rapidly changing, multi-variant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases and organometallics. Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods. All of these areas create both opportunities and challenges during adoption as enabling technologies.
dc.description.sponsorshipThe authors gratefully acknowledge support from UK Engineering and Physical Sciences Research Council (SVL and RMM), Woolf Fisher Trust (DEF) and Pfizer Worldwide Research and Development (CB, RJI).
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.subjectorganic methodologyen
dc.subjectsustainable chemistryen
dc.subjectmachine-assisted synthesisen
dc.titleMachine Assisted Organic Synthesisen
dc.typeArticle
dc.description.versionThis is the accepted manuscript. The final version is available at http://onlinelibrary.wiley.com/doi/10.1002/anie.201410744/abstract.en
prism.endingPage3464
prism.publicationDate2015en
prism.publicationNameAngewandte Chemie International Edition (English)en
prism.startingPage3449
prism.volume54en
dc.rioxxterms.funderEPSRC
rioxxterms.versionofrecord10.1002/anie.201410744en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015en
dc.contributor.orcidLey, Steven [0000-0002-7816-0042]
dc.contributor.orcidFitzpatrick, Daniel [0000-0003-3462-1852]
dc.contributor.orcidBattilocchio, Claudio [0000-0002-4601-8527]
dc.identifier.eissn1521-3773
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/K009494/1)
rioxxterms.freetoread.startdate2016-01-13


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