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dc.contributor.authorThaker, Youg Rajen
dc.contributor.authorRudd, Christopheren
dc.date.accessioned2015-06-03T14:04:04Z
dc.date.available2015-06-03T14:04:04Z
dc.date.issued2015-03-02en
dc.identifier.citationThaker and Rudd Inflammation & Cell Signaling (2015) 2: e613. DOI: 10.14800/ics.613en
dc.identifier.issn2330-779X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248224
dc.description.abstractThe transcription factor nuclear factor-kB (NF-kB) is critical for the induction of inflammatory responses in T-cells, survival and differentiation. Antigen receptor (TCR) and co-receptor CD28 are the central regulators of NF-kB activation in T-cells. Progress in understanding NF-kB activation in T-cells has occurred over the years with the identification of individual adapters such as ADAP and GRB-2 and enzymes such as PKC-θ that regulate NF-kB. However, little is known whether the engagement of distinct modules by the TCR and CD28 account for the cooperative effects of the two receptors in activating NF-kB. In this review, we discuss recent advances in our understanding of NF-kB regulation by TCR and CD28.
dc.description.sponsorshipThis work was supported by Wellcome Trust Program Grant (PG) PKAG/504 to Principal Research Fellow (PRF) C.E. Rudd.
dc.languageEnglishen
dc.language.isoenen
dc.publisherSmart Science & Technology
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectAdaptorsen
dc.subjectADAPen
dc.subjectVAV-1en
dc.subjectGRB-2en
dc.subjectNF-kBen
dc.titleDistinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cellsen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Smart Science & Technology via http://dx.doi.org/10.14800/ics.613en
prism.numbere613en
prism.publicationDate2015en
prism.publicationNameInflammation & Cell Signalingen
prism.volume2en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectidPKAG/504
rioxxterms.versionofrecord10.14800/ics.613en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-03-02en
dc.identifier.eissn2330-7803
rioxxterms.typeJournal Article/Reviewen


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales