Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.
J Gen Virol
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Poole, E., Lau, J. C., & Sinclair, J. (2015). Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.. J Gen Virol, 96 2355-2359. https://doi.org/10.1099/vir.0.000180
Latent infection of primary CD34(+) progenitor cells by human cytomegalovirus (HCMV) results in their increased survival in the face of pro-apoptotic signals. For instance, we have shown previously that primary myeloid cells are refractory to FAS-mediated killing and that cellular IL-10 (cIL-10) is an important survival factor for this effect. However, how cIL-10 mediates this protection is unclear. Here, we have shown that cIL-10 signalling leading to upregulation of the cellular factor PEA-15 mediates latency-associated protection of CD34(+) progenitor cells from the extrinsic death pathway.
We gratefully acknowledge funding from the UK Medical Research Council (J.H.S. G:0701279) which supports the current research in our laboratory and also the support of NIHR UK Biomedical Research Centre (J.H.S.). We thank Linda Teague, Roy Whiston and Stuart McGregor Dallas for technical support and Stuart McGregor Dallas for providing validation data for figure 1.
Medical Research Council (MR/K021087/1)
Medical Research Council (G0701279)
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External DOI: https://doi.org/10.1099/vir.0.000180
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248311
Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/