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dc.contributor.authorPoole, Emma
dc.contributor.authorLau, Jonathan CH
dc.contributor.authorSinclair, John
dc.date.accessioned2015-06-08T11:21:03Z
dc.date.available2015-06-08T11:21:03Z
dc.date.issued2015-08
dc.identifier.citationJournal of General Virology, August 2015 96: 2355-2359, doi: 10.1099/vir.0.000180
dc.identifier.issn0022-1317
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248311
dc.description.abstractLatent infection of primary CD34(+) progenitor cells by human cytomegalovirus (HCMV) results in their increased survival in the face of pro-apoptotic signals. For instance, we have shown previously that primary myeloid cells are refractory to FAS-mediated killing and that cellular IL-10 (cIL-10) is an important survival factor for this effect. However, how cIL-10 mediates this protection is unclear. Here, we have shown that cIL-10 signalling leading to upregulation of the cellular factor PEA-15 mediates latency-associated protection of CD34(+) progenitor cells from the extrinsic death pathway.
dc.description.sponsorshipWe gratefully acknowledge funding from the UK Medical Research Council (J.H.S. G:0701279) which supports the current research in our laboratory and also the support of NIHR UK Biomedical Research Centre (J.H.S.). We thank Linda Teague, Roy Whiston and Stuart McGregor Dallas for technical support and Stuart McGregor Dallas for providing validation data for figure 1.
dc.languageEnglish
dc.language.isoen
dc.publisherMicrobiology Society
dc.rightsAttribution 2.0 UK: England & Wales
dc.rightsCreative Commons Attribution License 2.0 UK
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.titleLatent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.
dc.typeArticle
dc.description.versionThis is the final version. It first appeared at http://jgv.sgmjournals.org/content/journal/jgv/10.1099/vir.0.000180.
prism.endingPage2359
prism.publicationDate2015
prism.publicationNameJ Gen Virol
prism.startingPage2355
prism.volume96
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidG:0701279
rioxxterms.versionofrecord10.1099/vir.0.000180
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-05-08
dc.contributor.orcidPoole, Emma [0000-0003-3904-6121]
dc.contributor.orcidSinclair, John [0000-0002-2616-9571]
dc.identifier.eissn1465-2099
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/K021087/1)
pubs.funder-project-idMedical Research Council (G0701279)
cam.issuedOnline2015-05-08
rioxxterms.freetoread.startdate2050-01-01


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales