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dc.contributor.authorJenkins, Valerieen
dc.contributor.authorFallowfield, Lesleyen
dc.contributor.authorLangridge, Carolynen
dc.contributor.authorBarrett, Jessicaen
dc.contributor.authorRyan, Andyen
dc.contributor.authorJacobs, Ianen
dc.contributor.authorKilkerr, Justineen
dc.contributor.authorMenon, Ushaen
dc.contributor.authorFarewell, Vernonen
dc.date.accessioned2015-06-17T10:39:34Z
dc.date.available2015-06-17T10:39:34Z
dc.date.issued2015-10en
dc.identifier.citationInternational Journal of Gynecological Cancer 2015, 25(8):1519–1525. doi:10.1097/IGC.0000000000000507
dc.identifier.issn1048-891X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248517
dc.description.abstractObjective: The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to establish the efficacy of two different ovarian cancer screening schedules. The psychosocial sub study examines the psychological factors associated with the screening programme. Methods: Women aged 50 to 75 years from 16 UK gynaecological centres randomised to annual multimodal screening (MM), or ultrasound screening (US) groups were followed for seven years. Psychosocial data from women who withdrew from the study following a repeat screen were examined. Results: 16% (3499/21733) of women requiring a repeat screening test in addition to annual screen withdrew from the study; 12.9% (1560/12073) from the MM group, and 20.1% (1939/9660) from the US group; an estimated relative risk of withdrawal of 1.46 (95%CI: [1.36, 1.56]; p=<0.001) for the US arm. High anxiety trait and increased psychological morbidity significantly influenced withdrawal even when age, screening centre, and group were taken into account (p<0.001). The risk of withdrawal decreased significantly the longer a woman stayed in UKCTOCS, irrespective of the number of screens and intensity in the preceding year. Conclusions: Withdrawal rate was greater in women undergoing US screening and in those who had repeats earlier in UKCTOCS. Having a high predisposition to anxiety, high current state anxiety and above threshold general psychological morbidity all increased the withdrawal rate.
dc.description.sponsorshipVF and JB were supported by the MRC (Unit Programme number U105261167 and grant number G0902100) and UM by National Institute for Health Research University College London Hospitals Biomedical Research Centre.
dc.languageEnglishen
dc.language.isoenen
dc.publisherLippincott Williams & Wilkins
dc.rightsAttribution-NonCommercial 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/uk/*
dc.subjectOvarian canceren
dc.subjectpopulation screening programmeen
dc.subjectwithdrawalen
dc.subjectanxietyen
dc.subjectpsychological morbidityen
dc.subjectUKCTOCSen
dc.titlePsychosocial factors associated with withdrawal from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) following one episode of repeat screeningen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Lippincott Williams & Wilkins via http://dx.doi.org/10.1097/IGC.0000000000000507en
prism.endingPage1525
prism.publicationDate2015en
prism.publicationNameInternational Journal of Gynecological Canceren
prism.startingPage1519
prism.volume25en
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidU105261167
dc.rioxxterms.projectidG0902100
rioxxterms.versionofrecord10.1097/IGC.0000000000000507en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10en
dc.contributor.orcidBarrett, Jessica [0000-0003-1889-9803]
dc.contributor.orcidFarewell, Vernon [0000-0001-6704-5295]
dc.identifier.eissn1525-1438
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idMRC (MR/K014811/1)
pubs.funder-project-idMRC (MR/L501566/1)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
rioxxterms.freetoread.startdate2016-04-01


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Attribution-NonCommercial 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 2.0 UK: England & Wales