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dc.contributor.authorDay, Felixen
dc.contributor.authorPerry, Johnen
dc.contributor.authorOng, Kennethen
dc.date.accessioned2015-06-18T08:09:53Z
dc.date.available2015-06-18T08:09:53Z
dc.date.issued2015-05-07en
dc.identifier.citationDay et al. Neuroendocrinology, 2015. DOI:10.1159/000431023.en
dc.identifier.issn0028-3835
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248536
dc.description.abstractUnderstanding the regulation of pubertal timing has relevance to developmental and human biology, and to the pathogenesis of various diseases. Recent large-scale genome-wide association studies for puberty timing and adult height, body mass index (BMI) and central body shape provide evidence for shared biological mechanisms that regulate these traits. There is substantial genetic overlap between age at menarche in women and BMI, with almost invariable directional consistency with the epidemiological associations between earlier menarche and higher BMI. By contrast, the genetic loci identified for age at menarche are largely distinct from those identified for central body shape, while alleles that confer earlier menarche can be associated with taller or shorter adult height. The findings of population-based studies for age at menarche show increasing relevance for other studies of rare monogenic disorders and enrich our understanding of the mechanisms that regulate the timing of puberty and reproductive function.
dc.description.sponsorshipThis work was supported by the MRC.
dc.languageEnglishen
dc.language.isoenen
dc.publisherKarger
dc.subjectpubertyen
dc.subjectgeneticsen
dc.subjectmenarcheen
dc.subjectimprinted genesen
dc.subjectBMIen
dc.subjectobesityen
dc.titleGenetic regulation of puberty timing in humansen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Karger at http://www.karger.com/Article/Abstract/431023en
prism.publicationDate2015en
prism.publicationNameNeuroendocrinologyen
dc.rioxxterms.funderMRC
dcterms.dateAccepted2015-04-28en
rioxxterms.versionofrecord10.1159/000431023en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-05-07en
dc.contributor.orcidDay, Felix [0000-0003-3789-7651]
dc.contributor.orcidPerry, John [0000-0001-6483-3771]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.identifier.eissn1423-0194
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idMedical Research Council (MC_U106179472)


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