Mendelian randomization: where are we now and where are we going?
Change log
Authors
Burgess, Stephen https://orcid.org/0000-0001-5365-8760
Timpson, Nicholas J
Ebrahim, Shah
Davey Smith, George
Abstract
The methodology and application of Mendelian randomization to study causal mechanisms in health and disease has developed dramatically over the last decade. New methods, large-scale genome-wide analyses, molecular epigenetics, and other new -omics technologies are all providing exceptional opportunities for the exploitation of Mendelian randomization approaches to understand causes of complex traits and disease outcomes. This research has the potential to identify new approaches for the prevention and treatment of common conditions.
Description
Keywords
Causality, Classification, Epidemiologic Research Design, Forecasting, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Metabolomics, Phenotype, Random Allocation, Sample Size
Journal Title
Int J Epidemiol
Conference Name
Journal ISSN
0300-5771
1464-3685
1464-3685
Volume Title
44
Publisher
Oxford University Press (OUP)
Publisher DOI
Sponsorship
Medical Research Council (MR/L003120/1)
British Heart Foundation (None)
British Heart Foundation (None)