Machines vs Malaria: a flow-based preparation of the drug candidate OZ439
Merchant, Rohan R
Souto, José A
Berry, Malcolm B
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Lau, S. H., Galván, A., Merchant, R. R., Battilocchio, C., Souto, J. A., Berry, M. B., & Ley, S. (2015). Machines vs Malaria: a flow-based preparation of the drug candidate OZ439. Organic Letters, 17 3218-3221. https://doi.org/10.1021/acs.orglett.5b01307
An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.
We are grateful to Croucher Foundation and Cambridge Trust (SHL), MEC-Spain (FPU-predoctoral grants, AG), Pfizer World-wide Research and Development (CB), the Xunta de Galicia Gov-ernment (JAS), and the EPSRC (SVL, grant n° EP/K0099494/1 and EP/K039520/1) for financial support.
External DOI: https://doi.org/10.1021/acs.orglett.5b01307
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248664
Attribution 2.0 UK: England & Wales, Creative Commons Attribution License 2.0 UK
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/