Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.
Change log
Authors
Lau, Shing-Hing
Galván, Alicia
Merchant, Rohan R
Battilocchio, Claudio https://orcid.org/0000-0002-4601-8527
Souto, José A
Abstract
An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.
Description
Keywords
Adamantane, Antimalarials, Malaria, Molecular Structure, Peroxides
Journal Title
Org Lett
Conference Name
Journal ISSN
1523-7060
1523-7052
1523-7052
Volume Title
17
Publisher
American Chemical Society (ACS)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K009494/1)
We are grateful to Croucher Foundation and Cambridge Trust (SHL), MEC-Spain (FPU-predoctoral grants, AG), Pfizer World-wide Research and Development (CB), the Xunta de Galicia Gov-ernment (JAS), and the EPSRC (SVL, grant n° EP/K0099494/1 and EP/K039520/1) for financial support.