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Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.


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Type

Article

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Authors

Lau, Shing-Hing 
Galván, Alicia 
Merchant, Rohan R 
Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Souto, José A 

Abstract

An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.

Description

Keywords

Adamantane, Antimalarials, Malaria, Molecular Structure, Peroxides

Journal Title

Org Lett

Conference Name

Journal ISSN

1523-7060
1523-7052

Volume Title

17

Publisher

American Chemical Society (ACS)
Sponsorship
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/K009494/1)
We are grateful to Croucher Foundation and Cambridge Trust (SHL), MEC-Spain (FPU-predoctoral grants, AG), Pfizer World-wide Research and Development (CB), the Xunta de Galicia Gov-ernment (JAS), and the EPSRC (SVL, grant n° EP/K0099494/1 and EP/K039520/1) for financial support.