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dc.contributor.authorRandle, Suzanneen
dc.contributor.authorLaman, Heikeen
dc.date.accessioned2015-06-24T14:45:56Z
dc.date.available2015-06-24T14:45:56Z
dc.date.issued2016-03-11en
dc.identifier.citationRandle and Laman. Current Protein & Peptide Science (2015)en
dc.identifier.issn1389-2037
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248685
dc.description.abstractFbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)-type E3 ubiquitin ligase and also has SCF-independent activities. Mutations within FBXO7 have been found to cause an early-onset Parkinson’s disease, and these are found within or near to its functional domains, including its F-box domain (FBD), its proline rich region (PRR), and its ubiquitin-like domain (Ubl). We highlight recent advances in our understanding of Fbxo7 function in Parkinson’s disease, with respect to these mutations and where they occur in the Fbxo7 protein. We hypothesize that many of Fbxo7 functions contribute to its role in PD pathogenesis.
dc.languageEnglishen
dc.language.isoenen
dc.publisherBentham Science
dc.subjectFbxo7/PARK15en
dc.subjectF-box proteinen
dc.subjectSCF-ligaseen
dc.subjectubiquitinen
dc.subjectE3 ligaseen
dc.subjectParkinson’s diseaseen
dc.subjectmitophagyen
dc.titleStructure and function of Fbxo7/PARK15 in Parkinson’s diseaseen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Bentham Science via https://doi.org/10.2174/1389203717666160311121433en
prism.endingPage724
prism.publicationDate2016en
prism.publicationNameCurrent Protein & Peptide Scienceen
prism.startingPage715
prism.volume18en
dcterms.dateAccepted2016-06-30en
rioxxterms.versionofrecord10.2174/1389203717666160311121433en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-03-11en
dc.contributor.orcidLaman, Heike [0000-0002-6089-171X]
dc.identifier.eissn1875-5550
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/J007846/1)
rioxxterms.freetoread.startdate2017-03-11


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