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dc.contributor.authorKolahgar, Golnaren
dc.contributor.authorSuijkerbuijk, Saskia JEen
dc.contributor.authorKucinski, Iwoen
dc.contributor.authorPoirier, Enzo Zen
dc.contributor.authorMansour, Sarahen
dc.contributor.authorSimons, Benjaminen
dc.contributor.authorPiddini, Eugeniaen
dc.date.accessioned2015-06-25T09:03:06Z
dc.date.available2015-06-25T09:03:06Z
dc.date.issued2015-07-23en
dc.identifier.citationDevelopmental Cell 2015, 34(3), 297-309. doi: 10.1016/j.devcel.2015.06.010en
dc.identifier.issn1534-5807
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248694
dc.description.abstractThrough their lifetime cells may suffer insults that reduce their fitness and disrupt their function and it is unclear how these potentially harmful cells are managed in adult tissues. We address this question using the adult Drosophila posterior midgut as model of homeostatic tissue and ribosomal Minute mutations to reduce fitness in groups of cells. We take a quantitative approach combining lineage tracing and biophysical modeling and address how cell competition affects stem cell and tissue population dynamics. We show that healthy cells induce clonal extinction in weak tissues, targeting both stem and differentiated cells for elimination. We also find that competition induces stem cell proliferation and self-renewal in healthy tissue, promoting selective advantage and tissue colonization. Finally, we show that winner cell proliferation is fuelled by the JAK-STAT ligand Unpaired-3, produced by Minute-/+ cells in response to chronic JNK stress signaling.
dc.description.sponsorshipThis work was supported by a Cancer Research UK Programme Grant (E.P. and G.K. A12460), a Royal Society University Research fellowship to E.P. (UF090580), an EMBO Long-Term Fellowship (ALTF 1476-2012), NWO Rubicon grant (825.12.027) and a Dutch Cancer Society Fellowship (BUIT-2013-5847) to S.J.E.S, a Wellcome Trust PhD studentships to IK and Core grant funding from the Wellcome Trust Core (092096) and CRUK (C6946/A14492).
dc.languageEnglishen
dc.language.isoenen
dc.publisherCell/Elsevier
dc.subjectCell competitionen
dc.subjectDrosophilaen
dc.subjectstem cellsen
dc.subjecttissue homeostasisen
dc.subjectinflammatory responseen
dc.subjectposterior midguten
dc.subjectribosomopathiesen
dc.subjectself-renewalen
dc.subjectcell deathen
dc.subjectJNK signalingen
dc.subjectJAK-STAT signalingen
dc.subjectMinuteen
dc.titleCell competition modifies adult stem cell and tissue population dynamics in a JAKSTAT dependent manneren
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.devcel.2015.06.010en
prism.endingPage309
prism.publicationDate2015en
prism.publicationNameDevelopmental Cellen
prism.startingPage297
prism.volume34en
dc.rioxxterms.funderCRUK
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectidA12460
dc.rioxxterms.projectid092096
dc.rioxxterms.projectidC6946/A14492
dcterms.dateAccepted2015-06-11en
rioxxterms.versionofrecord10.1016/j.devcel.2015.06.010en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-07-23en
dc.contributor.orcidKolahgar, Golnar [0000-0003-4007-3311]
dc.contributor.orcidKucinski, Iwo [0000-0002-9385-0359]
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.contributor.orcidPiddini, Eugenia [0000-0003-3901-076X]
dc.identifier.eissn1878-1551
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (098357/Z/12/Z)
pubs.funder-project-idCancer Research UK (12460)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idNetherlands Organisation for Scientific Research (NWO) (File No: 82512027)
pubs.funder-project-idCancer Research UK (A14492)


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