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dc.contributor.authorKarachaliou, Andromachi
dc.contributor.authorConlan, Andrew JK
dc.contributor.authorPreziosi, Marie-Pierre
dc.contributor.authorTrotter, Caroline L
dc.date.accessioned2015-07-01T11:24:18Z
dc.date.available2015-07-01T11:24:18Z
dc.date.issued2015-11-15
dc.identifier.citationClinical Infectious Diseases 2015, 61(suppl 5):S594-S600. doi:10.1093/cid/civ508
dc.identifier.issn1058-4838
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248770
dc.description.abstractBACKGROUND: The introduction of MenAfriVac in campaigns targeting people aged 1-29 years across the African meningitis belt has successfully reduced meningitis incidence and carriage due to Neisseria meningitidis group A (MenA). It is important to consider how best to sustain population protection in the long term. METHODS: We created a mathematical model of MenA transmission and disease to investigate the potential impact of a range of immunization strategies. The model is age structured; includes classes of susceptible, carrier, ill, and immune people (who may be vaccinated or unvaccinated); and incorporates seasonal transmission and a stochastic forcing term that models between year variation in rates of transmission. Model parameters were primarily derived from African sources. The model can describe the typical annual incidence of meningitis in the prevaccine era, with irregular epidemics of varying size. Parameter and structural uncertainty were explored in sensitivity analyses. RESULTS: Following MenAfriVac introduction at high uptake, the model predicts excellent short-term disease control. With no subsequent immunization, strong resurgences in disease incidence were predicted after approximately 15 years (assuming 10 years' average vaccine protection). Routine immunization at 9 months of age resulted in lower average annual incidence than regular mass campaigns of 1- to 4-year-olds, provided coverage was above approximately 60%. The strategy with the lowest overall average annual incidence and longest time to resurgence was achieved using a combination strategy of introduction into the Expanded Programme on Immunization at 9 months, 5 years after the initial mass campaigns, with a catch-up targeting unvaccinated 1- to 4-year-olds. CONCLUSIONS: These results can be used to inform policy recommendations for long-term vaccination strategies with MenAfriVac.
dc.description.sponsorshipThis work was funded by a grant from the Meningitis Vaccine Project (via PATH). Caroline Trotter received salary support from the MenAfriCar project, funded by grants from the Wellcome Trust and the Bill and Melinda Gates Foundation. This article appeared as part of the supplement ‘The development, licensure, introduction and impact of a new Group A meningococcal conjugate vaccine for Africa’ sponsored by the Bill & Melinda Gates Foundation.
dc.languageEnglish
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.rightsCreative Commons Attribution 4.0
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMeningitis
dc.subjectVaccine
dc.subjectAfrica
dc.subjectMathematical modelling
dc.titleModeling Long-term Vaccination Strategies With MenAfriVac in the African Meningitis Belt.
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/cid/civ508
prism.endingPageS600
prism.publicationDate2015
prism.publicationNameClin Infect Dis
prism.startingPageS594
prism.volume61
dc.rioxxterms.funderWellcome Trust
rioxxterms.versionofrecord10.1093/cid/civ508
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-11-15
dc.contributor.orcidConlan, Andrew [0000-0002-2593-6353]
dc.contributor.orcidTrotter, Caroline [0000-0003-4000-2708]
dc.identifier.eissn1537-6591
rioxxterms.typeJournal Article/Review
pubs.funder-project-idProgram for Appropriate Technology in Health (PATH) (GAT0779-06290-COL)
pubs.funder-project-idWellcome Trust (100891/Z/13/Z)
cam.issuedOnline2015-11-09


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Creative Commons Attribution 4.0
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0