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dc.contributor.authorHvoslef-Eide, Marthaen
dc.contributor.authorMar, ACen
dc.contributor.authorNilsson, SROen
dc.contributor.authorAlsiö, Jen
dc.contributor.authorHeath, CJen
dc.contributor.authorSaksida, Lisaen
dc.contributor.authorRobbins, Trevoren
dc.contributor.authorBussey, Timothyen
dc.date.accessioned2015-07-07T14:26:53Z
dc.date.available2015-07-07T14:26:53Z
dc.date.issued2015-07-24en
dc.identifier.citationJournal of Psychopharmacology 2015. doi: 10.1007/s00213-015-4007-xen
dc.identifier.issn0033-3158
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248850
dc.description.abstractRationale The NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://www.newmeds-europe.com) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia. Objectives This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere. Methods The battery consists of the 5-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a 3-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel nonmatching-to-sample based tasks for measuring spatial working memory and paired-associates learning for measuring long term memory. Results The rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks. Conclusion This battery of tests constitutes an extensive tool package for both model characterisation and preclinical drug discovery.
dc.description.sponsorshipThis work was supported by the Innovative Medicine Initiative Joint Undertaking under grant agreement no. 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013). The authors thank Charlotte Oomen for valuable comments on the manuscript.
dc.languageEnglishen
dc.language.isoenen
dc.publisherSpringer
dc.subjectDrug discoveryen
dc.subjectneuropsychiatric diseaseen
dc.subjectattentionen
dc.subjectworking memoryen
dc.subjectlong-term memoryen
dc.subjectexecutive functionen
dc.subjectcognitive flexibilityen
dc.subjectresponse inhibitionen
dc.subjectraten
dc.subjectmouseen
dc.titleThe NEWMEDS rodent touchscreen test battery for cognition relevant to schizophreniaen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00213-015-4007-xen
prism.publicationDate2015en
prism.publicationNameJournal of Psychopharmacologyen
dc.rioxxterms.funderEU FP7
dcterms.dateAccepted2015-06-26en
rioxxterms.versionofrecord10.1007/s00213-015-4007-xen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-07-24en
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.identifier.eissn1432-2072
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEC FP7 CP (115008)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)


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