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dc.contributor.authorVoon, Valerieen
dc.contributor.authorChang-Webb, Yee Chienen
dc.contributor.authorMorris, Laurelen
dc.contributor.authorCooper, Ellaen
dc.contributor.authorSethi, Arjunen
dc.contributor.authorBaek, Kwangyeolen
dc.contributor.authorGrant, Jonen
dc.contributor.authorRobbins, Trevoren
dc.contributor.authorHarrison, Neil Aen
dc.date.accessioned2015-07-07T15:55:07Z
dc.date.available2015-07-07T15:55:07Z
dc.date.issued2015-07-01en
dc.identifier.citationVoon et al. International Journal of Neuropsychopharmacology (2015). DOI: 10.1093/ijnp/pyv074en
dc.identifier.issn1461-1457
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248855
dc.description.abstractBackground: The ability to wait and to weigh evidence is critical to behavioural regulation. These behaviors are known as waiting and reflection impulsivity. In Study 1, we examined the effects of methylphenidate (MPH), a dopamine and norepinephrine reuptake inhibitor, on waiting and reflection impulsivity in healthy young individuals. In Study 2, we assessed the role of learning from feedback in disorders of addiction. Methods: We used the recently developed 4-Choice Serial Reaction Time task and the Beads task. Twenty-eight healthy volunteers were tested twice in a randomized double-blind placebo controlled cross-over trial with 20mg MPH. In the second study we analyzed premature responses as a function of prior feedback in disorders of addiction. Results: Study 1: MPH was associated with greater waiting impulsivity to a cue predicting reward along with faster responding to target onset without a generalized effect on reaction time or attention. MPH influenced reflection impulsivity based on baseline impulsivity. Study 2: more premature responses occurred after premature responses in stimulant dependent subjects. Conclusions: We show that MPH has dissociable effects on waiting and reflection impulsivity. Chronic stimulant exposure impairs learning from prior premature responses suggesting a failure to learn that premature responding is suboptimal. These findings provide a greater mechanistic understanding of waiting impulsivity.
dc.description.sponsorshipVV and NAH are Wellcome Trust (WT) intermediate Clinical Fellows. LSM is an MRC student. The BCNI is supported by a WT and MRC grant. The authors report no conflicts of interest. TWR consults for Cambridge Cognition, Lundbeck, Teva, Shire Pharmaceuticals, Otsuka, has research grants from Lundbeck, GSK. Royalties Cambridge Cognition and receives editorial honoraria from Springer, Elsevier.
dc.languageEnglishen
dc.language.isoenen
dc.publisherOxford University Press
dc.rightsCreative Commons Attribution 4.0
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaddictionen
dc.subjectbrain drinkingen
dc.subjectimpulsivityen
dc.subjectmethylphenidateen
dc.subjectpremature respondingen
dc.subjectstimulant dependenceen
dc.titleWaiting impulsivity : the influence of acute methylphenidate and feedbacken
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/ijnp/pyv074en
prism.publicationDate2015en
prism.publicationNameInternational Journal of Neuropsychopharmacologyen
dc.rioxxterms.funderWellcome Turst
dc.rioxxterms.funderMRC
dcterms.dateAccepted2015-06-24en
rioxxterms.versionofrecord10.1093/ijnp/pyv074en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-07-01en
dc.contributor.orcidVoon, Valerie [0000-0001-6790-1776]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.identifier.eissn1469-5111
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (093705/Z/10/Z)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)


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Creative Commons Attribution 4.0
Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0