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dc.contributor.authorMartínez, A
dc.contributor.authorBlanco, MD
dc.contributor.authorDavidenko, N
dc.contributor.authorCameron, RE
dc.date.accessioned2015-07-09T11:25:48Z
dc.date.available2015-07-09T11:25:48Z
dc.date.issued2015-11-05
dc.identifier.citationMartinez et al. Carbohydrate Polymers (2015) Vol. 132, pp. 606-619. doi: 10.1016/j.carbpol.2015.06.084
dc.identifier.issn0144-8617
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248873
dc.description.abstractChitosan/collagen (Chit/Col) blends have demonstrated great potential for use in tissue engineering (TE) applications. However, there exists a lack of detailed study on the influence of important design parameters (i.e, component ratio or crosslinking methods) on the essential properties of the scaffolds (morphology, mechanical stiffness, swelling, degradation and cytotoxicity). This work entailed a systematic study of these essential properties of three Chit/Col compositions, covering a wide range of component ratios and using different crosslinking methods. Our results showed the possibility of tailoring these properties by changing component ratios, since different interactions occurred between Chit/Col: samples with Chit-enriched compositions showed a hydrogen-bonding type complex (HC), whereas a self-crosslinking phenomenon was induced in Col-enriched scaffolds. Additionally, material and biological properties of the resultant matrices were further adjusted and tuned by changing crosslinking conditions. In such way, we obtained a wide range of scaffolds whose properties were tailored to meet specific needs of TE applications.
dc.description.sponsorshipThe authors are grateful to Dr. von Kobbe (Chimera Pharma of Bionostra Group) for the gift of MCF7 cells. The financial support of the Ministerio de Ciencia e Innovación of Spain (FIS PS09/01513), and the FPI grant from UCM to A. Martínez are gratefully acknowledged.
dc.languageEnglish
dc.language.isoen
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/
dc.subjectcollagen
dc.subjectchitosan
dc.subjectscaffolds
dc.subjectcrosslinking (XL)
dc.subjecttissue engineering (TE)
dc.titleTailoring chitosan/collagen scaffolds for tissue engineering: Effect of composition and different crosslinking agents on scaffold properties.
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.carbpol.2015.06.084
prism.endingPage619
prism.publicationDate2015
prism.publicationNameCarbohydr Polym
prism.startingPage606
prism.volume132
dcterms.dateAccepted2015-06-27
rioxxterms.versionofrecord10.1016/j.carbpol.2015.06.084
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-07-09
dc.contributor.orcidCameron, Ruth [0000-0003-1573-4923]
dc.identifier.eissn1879-1344
rioxxterms.typeJournal Article/Review
cam.issuedOnline2015-07-09
rioxxterms.freetoread.startdate2016-07-09


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