Functional roles of non-coding Y RNAs.
Kowalski, Madzia P
Int J Biochem Cell Biol
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Kowalski, M. P., & Krude, T. (2015). Functional roles of non-coding Y RNAs.. Int J Biochem Cell Biol, 66 20-29. https://doi.org/10.1016/j.biocel.2015.07.003
Non-coding RNAs are involved in a multitude of cellular processes but the biochemical function of many small non-coding RNAs remains unclear. The family of small non-coding Y RNAs is conserved in vertebrates and related RNAs are present in some prokaryotic species. Y RNAs are also homologous to the newly identified family of non-coding stem-bulge RNAs (sbRNAs) in nematodes, for which potential physiological functions are only now emerging. Y RNAs are essential for the initiation of chromosomal DNA replication in vertebrates and, when bound to the Ro60 protein, they are involved in RNA stability and cellular responses to stress in several eukaryotic and prokaryotic species. Additionally, short fragments of Y RNAs have recently been identified as abundant components in the blood and tissues of humans and other mammals, with potential diagnostic value. While the number of functional roles of Y RNAs is growing, it is becoming increasingly clear that the conserved structural domains of Y RNAs are essential for distinct cellular functions. Here, we review the biochemical functions associated with these structural RNA domains, as well as the functional conservation of Y RNAs in different species. The existing biochemical and structural evidence supports a domain model for these small non-coding RNAs that has direct implications for the modular evolution of functional non-coding RNAs.
DNA replication, Non-coding RNA, RNA domains, RNA stability, Y RNA, Animals, Base Sequence, DNA Replication, Humans, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Untranslated, Ribonucleoproteins
Research in the authors’ laboratory has been funded by grants from Cancer Research UK (CRUK), the Association for International Cancer Research (AICR) and the Biotechnology and Biological Sciences Research Council (BBSRC).
Worldwide Cancer Research (10-0570)
External DOI: https://doi.org/10.1016/j.biocel.2015.07.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/248909
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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